4-SUBSTITUTED FUSED HETEROPYRIMIDINES AND FUSED HETERO-4-PYRIMIDONES

Title:

4-SUBSTITUTED FUSED HETEROPYRIMIDINES AND FUSED HETERO-4-PYRIMIDONES

Document Type and Number:

WIPO Patent Application WO2003057149

Kind Code:

B1

Abstract:

The invention relates to 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B (PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma. The invention also relates to processes for preparing 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones and processes for preparing compositions containing the same.

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Inventors:

SCOTT WILLIAM J (US)
BIERER DONALD E (US)
STOLLE ANDREAS (DE)
CHEN YUANWEI (US)

Application Number:

PCT/US2002/041428

Publication Date:

February 19, 2004

Filing Date:

December 27, 2002

Export Citation:

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Assignee:

BAYER AG (US)
SCOTT WILLIAM J (US)
BIERER DONALD E (US)
STOLLE ANDREAS (DE)
CHEN YUANWEI (US)

International Classes:

A61P11/06; A61P19/10; C07D487/04; C07D495/04; (IPC1-7): C07D239/70; A61K31/517; A61P11/06; A61P19/10

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