Title:
AMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2008/093737
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (I) or a pharmaceutically
acceptable salt thereof, which is useful as a renin inhibitor.
(I) wherein R1a represents a hydrogen atom, a C1-6 alkyl
group which may be substituted, or the like; R1b represents a C1-6
alkoxy group or the like; R1c represents a hydrogen atom, a C1-6
alkoxy group which may be substituted, or the like; R2 represents a
hydrogen atom, a C1-6 alkyl group which may be substituted, or the like;
R3a, R3b, R3c and R3d independently
represent a group: -A-B [wherein A represents a single bond, -(CH2)sO-,
-(CH2)sN(R4)CO- or the like, and B represent
a hydrogen atom, a C1-6 alkyl group which may be substituted, or the
like]; R4 represents a hydrogen atom, a C1-6 alkyl group
which may be substituted, or the like; s represents a number of 0 or the like, and
n represents a number of 1 or the like.
Inventors:
NAKAHIRA HIROYUKI (JP)
IKUMA YOHEI (JP)
FUKUDA NOBUHISA (JP)
KOBAYASHI TOMONORI (JP)
TOSAKI SHINYA (JP)
IKUMA YOHEI (JP)
FUKUDA NOBUHISA (JP)
KOBAYASHI TOMONORI (JP)
TOSAKI SHINYA (JP)
Application Number:
PCT/JP2008/051418
Publication Date:
August 07, 2008
Filing Date:
January 30, 2008
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
NAKAHIRA HIROYUKI (JP)
IKUMA YOHEI (JP)
FUKUDA NOBUHISA (JP)
KOBAYASHI TOMONORI (JP)
TOSAKI SHINYA (JP)
NAKAHIRA HIROYUKI (JP)
IKUMA YOHEI (JP)
FUKUDA NOBUHISA (JP)
KOBAYASHI TOMONORI (JP)
TOSAKI SHINYA (JP)
International Classes:
C07D207/14; A61K31/40; A61K31/439; A61K31/445; A61K31/4462; A61K31/45; A61K31/451; A61K31/55; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/06; A61P27/02; A61P27/06; A61P43/00; C07D211/56; C07D221/22; C07D223/12
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TETRAHEDRON LETTERS, vol. 46, 2005, pages 7495
"Protective groups in Organic Synthesis", JOHN WILEY & SONS, INC.
J. OR G. CHEM., vol. 70, 2005, pages 6956
J. OR G. CHEM., vol. 57, 1992, pages 7194
CHEM. PHARM. BULL., vol. 40, 1992, pages 102
J. MED. CHEM., vol. 26, 1983, pages 507
R. C. LAROQUE: "Comprehensive Organic transformation", vol. 61, 1989, VCH PUBLISHER INC., pages: 3849
SYNTHETIC COMMUNICATIONS, vol. 34, 2004, pages 219
TETRAHEDRON: ASYMMETRY, vol. 16, 2005, pages 2599
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
TETRAHEDRON: ASYMMETRY, vol. 17, 2006, pages 993
TETRAHEDRON: ASYMMETRY, vol. 8, 1997, pages 3685
J. OR G. CHEM., vol. 61, 1996, pages 6033
R. C. LAROQUE: "Comprehensive Organic transformation", 1989, VCH PUBLISHER INC
TETRAHEDRON LETTERS, vol. 43, 2002, pages 4275
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, 2005, pages 59
CHEM. PHARM. BULL., vol. 46, 1998, pages 1716
SYNTH. COMMUN., vol. 27, 1997, pages 2943
J. CHEM. SOC. PERKIN TRANS, vol. 2, 1988, pages 691
J. AM. CHEM. SOC., vol. 123, 2001, pages 6989
J. OR G. CHEM., vol. 70, 2005, pages 4360
SYNTH. COMMUN., vol. 29, 1999, pages 591
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 1621, 2006, pages 16
NAT REV DRUG DISCOV., vol. 1, no. 8, 2002, pages 621 - 36
CURR HYPERTENS REP., vol. 6, no. 2, 2004, pages 129 - 32
PHYSIOL. REV., vol. 86, 2006, pages 747 - 803
CURR DIAB REP., vol. 6, no. 1, 2006, pages 8 - 16
J HYPERTENS, vol. 23, no. 1, 2005, pages 9 - 17
J EXP MED., vol. 106, no. 3, 1957, pages 439 - 53
J AM SOC NEPHROL, vol. 16, 2005, pages 592 - 599
HYPERTENSION, vol. 42, no. 6, 2003, pages 137 - 43
CIRCULATION, vol. 111, no. 8, 2005, pages 10 12 - 8
J HYPERTENS, vol. 24, no. 4, 2006, pages 82
"Jikken-Kagaku-Koza", vol. 22, MARUZEN
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 46, 1998, pages 1716
J. COMBINATORIAL CHEMISTRY, vol. 8, 2006, pages 469
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC.
J. OR G. CHEM., vol. 71, 2006, pages 6522
J. ORG. CHEM., vol. 61, 1996, pages 3849
J. ORG. CHEM., vol. 68, 2003, pages 4120
J. ORG. CHEM., vol. 63, 1998, pages 370
J. ORG. CHEM., vol. 70, 2005, pages 2195
R. C. LAROQUE: "Comprehensive Organic transformation", 1989, VCH PUBLISHER INC.
TETRAHEDRON LETTERS, vol. 46, 2005, pages 7495
"Protective groups in Organic Synthesis", JOHN WILEY & SONS, INC.
J. OR G. CHEM., vol. 70, 2005, pages 6956
J. OR G. CHEM., vol. 57, 1992, pages 7194
CHEM. PHARM. BULL., vol. 40, 1992, pages 102
J. MED. CHEM., vol. 26, 1983, pages 507
R. C. LAROQUE: "Comprehensive Organic transformation", vol. 61, 1989, VCH PUBLISHER INC., pages: 3849
SYNTHETIC COMMUNICATIONS, vol. 34, 2004, pages 219
TETRAHEDRON: ASYMMETRY, vol. 16, 2005, pages 2599
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
TETRAHEDRON: ASYMMETRY, vol. 17, 2006, pages 993
TETRAHEDRON: ASYMMETRY, vol. 8, 1997, pages 3685
J. OR G. CHEM., vol. 61, 1996, pages 6033
R. C. LAROQUE: "Comprehensive Organic transformation", 1989, VCH PUBLISHER INC
TETRAHEDRON LETTERS, vol. 43, 2002, pages 4275
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, 2005, pages 59
CHEM. PHARM. BULL., vol. 46, 1998, pages 1716
SYNTH. COMMUN., vol. 27, 1997, pages 2943
J. CHEM. SOC. PERKIN TRANS, vol. 2, 1988, pages 691
J. AM. CHEM. SOC., vol. 123, 2001, pages 6989
J. OR G. CHEM., vol. 70, 2005, pages 4360
SYNTH. COMMUN., vol. 29, 1999, pages 591
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 1621, 2006, pages 16
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building3-7, Shiromi 1-chome, Chuo-ku,Osaka-sh, Osaka 01, JP)
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