Title:
ANTIBODY-DRUG CONJUGATES INCLUDING HEMIASTERLIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/031614
Kind Code:
A1
Abstract:
Compounds represented by formula (1-1) or salts thereof. [In the formula, b represents an integer from 1 to 5, and Z is a group represented by formula (Z-1), formula (Z-2), formula (Z-3), formula (Za-1), formula (Za-2), formula (Za-3), formula (Za-4), or formula (Za-5).]
More Like This:
Inventors:
BAN HITOSHI (JP)
SUWA ATSUSHI (JP)
TAKANASHI YOSUKE (JP)
SUWA ATSUSHI (JP)
TAKANASHI YOSUKE (JP)
Application Number:
PCT/JP2018/030143
Publication Date:
February 14, 2019
Filing Date:
August 10, 2018
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07K5/065; A61K38/06; A61K38/08; A61K39/395; A61K47/65; A61K47/68; A61P35/00; A61P43/00; C07K5/072; C07K5/078; C07K5/093; C07K16/28
Domestic Patent References:
WO2015151079A2 | 2015-10-08 | |||
WO2014057436A2 | 2014-04-17 | |||
WO2004026293A2 | 2004-04-01 | |||
WO1996033211A1 | 1996-10-24 | |||
WO2014144871A1 | 2014-09-18 | |||
WO2003082268A2 | 2003-10-09 | |||
WO2015095952A1 | 2015-07-02 | |||
WO2015095953A1 | 2015-07-02 | |||
WO2014057436A2 | 2014-04-17 | |||
WO2016123582A1 | 2016-08-04 |
Foreign References:
JPH11505211A | 1999-05-18 | |||
JP2016516063A | 2016-06-02 | |||
JP2011500725A | 2011-01-06 | |||
JP2012522513A | 2012-09-27 | |||
JP2017506234A | 2017-03-02 | |||
US7579323B1 | 2009-08-25 |
Other References:
TALPIR, R. ET AL., TETRAHEDRON LETT., vol. 35, 1994, pages 4453 - 4456
ZASK, A., BIOORG. MED. CHEM.LETT., vol. 14, 2004, pages 4353 - 4358
ZASK, A., J. MED. CHEM., vol. 47, 2004, pages 4774 - 4786
YAMASHITA, A., BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5317 - 5322
NIEMAN, J. A., J, NAT. PROD., vol. 66, 2003, pages 183 - 199
ROCHA-LIMA, C.M., CANCER, vol. 118, 2012, pages 4262 - 4270
ALLEY, S. C., BIOCONJUGATE CHEM., vol. 19, 2008, pages 759 - 765
BALDWIN, A. D., BIOCONJUGATE CHEM., vol. 22, 2011, pages 1946 - 1953
MOL. CANCER THER., vol. 14, 2015, pages 1614 - 1624
"Methods in Molecular Biology", vol. 1045, 2013, HUMANA PRESS, article "Antibody Drug Conjugates", pages: 267 - 284
DORONINA, S.O. ET AL., BIOCONJUGATE CHEM., vol. 17, 2006, pages 114 - 124
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
J. MED. CHEM., vol. 50, 2007, pages 4329 - 4339
TETRAHEDRON LETT., vol. 38, 1997, pages 317 - 320
J. NAT. PROD., vol. 66, 2003, pages 183 - 199
ORG. LETT., vol. 4, 2002, pages 695 - 697
J. ORG. CHEM., vol. 66, 2001, pages 7355 - 7364
TETRAHEDRON LETT., vol. 45, 2004, pages 495 - 499
BIOORG MED CHEM LETT., vol. 14, no. 21, 1 November 2004 (2004-11-01), pages 5317 - 22
J MED CHEM., vol. 47, no. 19, 9 September 2004 (2004-09-09), pages 4774 - 86
HAMBLETT K. J. ET AL., CLIN. CANCER RES., vol. 10, 2004, pages 7063 - 7070
"New Edition Toxicology", 2009, ASAKURA PUBLISHING CO., LTD.
See also references of EP 3666787A4
ZASK, A., BIOORG. MED. CHEM.LETT., vol. 14, 2004, pages 4353 - 4358
ZASK, A., J. MED. CHEM., vol. 47, 2004, pages 4774 - 4786
YAMASHITA, A., BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 5317 - 5322
NIEMAN, J. A., J, NAT. PROD., vol. 66, 2003, pages 183 - 199
ROCHA-LIMA, C.M., CANCER, vol. 118, 2012, pages 4262 - 4270
ALLEY, S. C., BIOCONJUGATE CHEM., vol. 19, 2008, pages 759 - 765
BALDWIN, A. D., BIOCONJUGATE CHEM., vol. 22, 2011, pages 1946 - 1953
MOL. CANCER THER., vol. 14, 2015, pages 1614 - 1624
"Methods in Molecular Biology", vol. 1045, 2013, HUMANA PRESS, article "Antibody Drug Conjugates", pages: 267 - 284
DORONINA, S.O. ET AL., BIOCONJUGATE CHEM., vol. 17, 2006, pages 114 - 124
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
J. MED. CHEM., vol. 50, 2007, pages 4329 - 4339
TETRAHEDRON LETT., vol. 38, 1997, pages 317 - 320
J. NAT. PROD., vol. 66, 2003, pages 183 - 199
ORG. LETT., vol. 4, 2002, pages 695 - 697
J. ORG. CHEM., vol. 66, 2001, pages 7355 - 7364
TETRAHEDRON LETT., vol. 45, 2004, pages 495 - 499
BIOORG MED CHEM LETT., vol. 14, no. 21, 1 November 2004 (2004-11-01), pages 5317 - 22
J MED CHEM., vol. 47, no. 19, 9 September 2004 (2004-09-09), pages 4774 - 86
HAMBLETT K. J. ET AL., CLIN. CANCER RES., vol. 10, 2004, pages 7063 - 7070
"New Edition Toxicology", 2009, ASAKURA PUBLISHING CO., LTD.
See also references of EP 3666787A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: