ANTIVIRAL BIFUNCTIONAL MOLECULES, METHODS OF CONSTRUCTION AND METHODS OF TREATING VIRUS-INDUCED CANCER THEREWITH

WIPO Patent Application WO2006103494

A3

The present invention relates to molecules that are capable of killing cells. The molecules comprise: a targeting agent and a channel-forming moiety. The molecules may be polypeptides. The present invention also relates to polynucleotide sequences encoding the polypeptides of the invention. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is an antibody. Methods of treatment by administering the molecules of the present invention are also provided.

WO/2002/034885	SERICIN-CONTAINING MATERIAL, PROCESS FOR PRODUCING THE SAME AND METHOD OF USING THE SAME
JP4146515	Bioluminescent new products
JP6722103	Cancer treatment methods and compositions

QIU XIAO-QING (CN)

PCT/IB2005/004155

December 07, 2006

December 09, 2005

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WEST CHINA HOSPITAL SICHUAN UNIV (CN)
QIU XIAO-QING (CN)

C07K14/435; A61K38/16; A61K38/17; A61K47/48; A61P31/12; A61P35/00; C07K14/195; C07K14/245; C07K16/08; C12N15/09; C12N15/12; C12N15/13; C12N15/31; C12N15/62; C12N15/63; C12N15/64; C12N15/85; C12P21/02

CN1482242A	2004-03-17
CN1661012A	2005-08-31
US20050153872A1	2005-07-14
CN1396178A	2003-02-12
CN1532282A	2004-09-29

DATABASE GENPEPT [online] 11 February 2000 (2000-02-11), MANKOVICH J.A. ET AL., XP003004458, Database accession no. (AAA23182)
BUGLI F. ET AL.: "Molecular profile of a human monoclonal antibody Fab fragment specific for Epstein-Barr virus gp350/220 antigen", HUMAN IMMUNOLOGY, vol. 62, no. 4, 2001, pages 362 - 367, XP003004459

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