Title:
APPLICATION OF 5-HYDROXYTRYPTAMINE RECEPTOR 1A IN PREPARING DRUG FOR PORTAL HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2019/149079
Kind Code:
A1
Abstract:
The present invention relates to the technical field of pharmaceuticals and specifically describes an application of a 5-hydroxytryptamine receptor 1A in preparing a drug for portal hypertension. The present invention achieved a significant decrease in portal venous pressure in model rats with cirrhotic portal hypertension by means of an HTR1A inhibitor WAY100635 administered at 1 mg/kg/day by intraperitoneal injection or alverine administered at 15 mg/kg/day by oral gavage . It follows that a 5-hydroxytryptamine receptor 1A antagonist can be used to prepare an experimental drug for the treatment of cirrhotic portal hypertension. Furthermore, the 5-hydroxytryptamine receptor 1A antagonist can also be used to prepare drugs for symptoms of portal hypertension syndrome, such as esophageal and fundal varices, rupture and bleeding, ascites, or hepatic encephalopathy. The present invention provides a novel treatment means to treat the manifestations of portal hypertension syndrome, such as esophageal and fundal varices, rupture and bleeding, ascites, or hepatic encephalopathy.
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Inventors:
XIE WEI-FEN (CN)
ZHU CHANG-PENG (CN)
ZHANG XIN (CN)
ZHU CHANG-PENG (CN)
ZHANG XIN (CN)
Application Number:
PCT/CN2019/072124
Publication Date:
August 08, 2019
Filing Date:
January 17, 2019
Export Citation:
Assignee:
SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV (CN)
International Classes:
A61K31/137; A61P9/12
Domestic Patent References:
| WO2011009012A1 | 2011-01-20 | |||
| WO1999029323A1 | 1999-06-17 | |||
| WO1997010824A1 | 1997-03-27 |
Foreign References:
| US20160375016A1 | 2016-12-29 | |||
| CN101766588A | 2010-07-07 |
Other References:
ANNE-MARIE COELHO , LUC JACOB , JEAN FIORAMONTI , LIONEL BUENO : "Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype", PHARMACEUTICAL AND CLINICAL RESEARCH, vol. 53, no. 10, 1 January 2001 (2001-01-01), pages 1419 - 1426, XP009025660, ISSN: 0022-3573, DOI: 10.1211/0022357011777783
K.A RAHN , Y-J CAO , C.W HENDRIX , A.I KAPLIN : "The role of 5-HT1A receptors in mediating acute negative effects of antidepressants: implications in pediatric depression", TRANSLATIONAL PSYCHIATRY, vol. 5, no. 5, 1 May 2015 (2015-05-01), pages 1 - 8, XP055627859, DOI: :10.1038/tp.2015.57
RICHARD G RUDDELL , DEREK A MANN , GRANT A RAMM: "The function of serotonin within the liver", JOURNAL OF HEPATOLOGY, vol. 48, no. 4, 28 January 2008 (2008-01-28), pages 666 - 675, XP022534928, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2008.01.006
MA YUNHAN, PAN YUFEI, DONG LIWEI, TAN YEXIONG: "Serotonin promoting the development and progression of hepatocellular carcinoma", TUMOR, vol. 36, no. 5, 31 May 2016 (2016-05-31), pages 521 - 529, XP009522439, ISSN: 1000-7431
See also references of EP 3747430A4
K.A RAHN , Y-J CAO , C.W HENDRIX , A.I KAPLIN : "The role of 5-HT1A receptors in mediating acute negative effects of antidepressants: implications in pediatric depression", TRANSLATIONAL PSYCHIATRY, vol. 5, no. 5, 1 May 2015 (2015-05-01), pages 1 - 8, XP055627859, DOI: :10.1038/tp.2015.57
RICHARD G RUDDELL , DEREK A MANN , GRANT A RAMM: "The function of serotonin within the liver", JOURNAL OF HEPATOLOGY, vol. 48, no. 4, 28 January 2008 (2008-01-28), pages 666 - 675, XP022534928, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2008.01.006
MA YUNHAN, PAN YUFEI, DONG LIWEI, TAN YEXIONG: "Serotonin promoting the development and progression of hepatocellular carcinoma", TUMOR, vol. 36, no. 5, 31 May 2016 (2016-05-31), pages 521 - 529, XP009522439, ISSN: 1000-7431
See also references of EP 3747430A4
Attorney, Agent or Firm:
SHANGHAI SUNHOLD LAW FIRM (CN)
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