Title:
APPLICATION OF PHOSPHODIESTERASE 4 INHIBITOR ZL-N-91 IN PREPARATION OF MEDICAMENT FOR TREATING PROSTATE CANCER PROLIFERATION AND METASTASIS
Document Type and Number:
WIPO Patent Application WO/2018/028560
Kind Code:
A1
Abstract:
Disclosed in the present invention is an application of a new type of phosphodiesterase 4 (PED4) inhibitor ZL-n-91 in the preparation of a medicament for treating prostate cancer proliferation and metastasis. Animal experiments which utilize mice and cell biological experiments show that, the phosphodiesterase 4 inhibitor ZL-n-91 of the present invention can significantly inhibit the proliferation and metastasis of prostate cancer cells, indicating that the phosphodiesterase 4 inhibitor ZL-n-91 is expected to become an important target of anti-proliferative and metastatic prostate cancer research, which provides the basis for the preparation of anti-prostate cancer proliferation and metastasis drugs; the present invention has good prospects with respect to development and application.
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Inventors:
ZHAO ALLAN ZIJIAN (CN)
GONG SIJIA (CN)
LIN YAN (CN)
LI FANGHONG (CN)
LI XIAOXI (CN)
ZHOU SUJIN (CN)
ZHAO ZHENGGANG (CN)
GONG SIJIA (CN)
LIN YAN (CN)
LI FANGHONG (CN)
LI XIAOXI (CN)
ZHOU SUJIN (CN)
ZHAO ZHENGGANG (CN)
Application Number:
PCT/CN2017/096399
Publication Date:
February 15, 2018
Filing Date:
August 08, 2017
Export Citation:
Assignee:
GUANGZHOU SINOGEN BIOMEDICAL TECH LTD (CN)
International Classes:
A61K31/341; A61P35/00; A61P35/04
Foreign References:
| CN101495454A | 2009-07-29 | |||
| CN102716110A | 2012-10-10 |
Other References:
POWERS, G.L. ET AL.: "Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential", MOL CANCER RES., vol. 13, no. 1, 15 January 2015 (2015-01-15), pages 149 - 160, XP055568013, ISSN: 1541-7786
GONG, SIJIA ET AL.: "Effects of a Selective Phosphodiesterase 4 Inhibitor, ZL-n-91, on the Human Prostate Cancer PC-3 Cells and Xenografts in Nude Mice", PROGRESS IN MODERN BIOMEDICINE, vol. 16, no. 24, 30 August 2016 (2016-08-30), pages 4601 - 4604, XP009513645, ISSN: 1673-6273, DOI: 10.13241/j.cnki.pmb.2016.24.001
RUIHONG MA; BIN-YAN YANG; CHANG-YOU WU: "A selective phosphodiesterase 4 (PDE4) inhibitor Zl-n-91 suppresses IL-17 production by human memory Thl7 cells", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 8, no. 10, 2008, pages 1408 - 1417, XP023521806, DOI: doi:10.1016/j.intimp.2008.05.012
See also references of EP 3498274A4
GONG, SIJIA ET AL.: "Effects of a Selective Phosphodiesterase 4 Inhibitor, ZL-n-91, on the Human Prostate Cancer PC-3 Cells and Xenografts in Nude Mice", PROGRESS IN MODERN BIOMEDICINE, vol. 16, no. 24, 30 August 2016 (2016-08-30), pages 4601 - 4604, XP009513645, ISSN: 1673-6273, DOI: 10.13241/j.cnki.pmb.2016.24.001
RUIHONG MA; BIN-YAN YANG; CHANG-YOU WU: "A selective phosphodiesterase 4 (PDE4) inhibitor Zl-n-91 suppresses IL-17 production by human memory Thl7 cells", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 8, no. 10, 2008, pages 1408 - 1417, XP023521806, DOI: doi:10.1016/j.intimp.2008.05.012
See also references of EP 3498274A4
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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