AQUEOUS SUSPENSION AGENT COMPRISING GLUCOCORTICOSTEROID NANOPARTICLES

Title:

AQUEOUS SUSPENSION AGENT COMPRISING GLUCOCORTICOSTEROID NANOPARTICLES

Document Type and Number:

WIPO Patent Application WO/2016/181935

Kind Code:

A1

Abstract:

[Problem] To provide an aqueous suspension comprising a glucocorticosteroid compound as an active ingredient. More particularly, to provide a practically usable medicinal composition that comprises a glucocorticosteroid compound as an active ingredient. [Solution] An aqueous suspension agent characterized by comprising nanoparticles of a glucocorticosteroid compound and a dispersion stabilizing agent; the aqueous suspension agent wherein the average particle diameter of the nanoparticles is 300 nm or less and the D90 particle diameter thereof is 450 nm or less; and a medicinal composition for parenteral administration, an injection, eye drops or ear drops comprising the aforesaid aqueous suspension, more particularly, eye drops for treating or preventing an inflammatory eye disease, or ear drops for treating or preventing an inflammatory ear disease.

Inventors:

TADA TAKAHIRO (JP)
KAGAMI KAZUHIRO (JP)
YOKOTA SHIRO (JP)
KIKUCHI KENTA (JP)

Application Number:

PCT/JP2016/063752

Publication Date:

November 17, 2016

Filing Date:

May 09, 2016

Export Citation:

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Assignee:

ACTIVUS PHARMA CO LTD (JP)

International Classes:

A61K31/57; A61K9/10; A61K31/573; A61K31/58; A61K47/10; A61K47/12; A61K47/24; A61K47/32; A61K47/34; A61K47/38; A61P29/00; A61P31/04

Domestic Patent References:

WO2008126797A1	2008-10-23
WO2010032434A1	2010-03-25
WO2014074823A1	2014-05-15

Foreign References:

JP2005536512A	2005-12-02
JP2003055262A	2003-02-26

Other References: