ASSAY TO MEASURE THE POTENCY OF RECEPTOR-LIGAND INTERACTIONS IN NANOMEDICINES

Title:

ASSAY TO MEASURE THE POTENCY OF RECEPTOR-LIGAND INTERACTIONS IN NANOMEDICINES

Document Type and Number:

WIPO Patent Application WO/2018/185564

Kind Code:

A3

Abstract:

Described herein, is an isolated cell comprising a recombinant T cell receptor (TCR) and a TCR- pathway-dependent reporter, wherein the recombinant T cell receptor is specific for a disease- relevant antigen bound to an MHC molecule. Also described are methods of use for the isolated cell as an assay to determine the function or potency of a peptide-major histocompatibility complex (pMHC) coupled to a nanoparticle (pMHC-NP) that can be used as a medicine for treating an autoimmune disease or cancer.

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Inventors:

SANTAMARIA PEDRO (CA)

Application Number:

PCT/IB2018/000510

Publication Date:

January 03, 2019

Filing Date:

April 05, 2018

Export Citation:

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Assignee:

UTI LP (CA)

International Classes:

C12N5/10; C07K14/725; C12N15/85; C12Q1/02

Domestic Patent References:

WO2008109852A2	2008-09-12
WO2016146505A1	2016-09-22

Other References:

SHAO, K. ET AL.: "Nanoparticle-Based Immunotherapy for Cancer", ACSNANO, vol. 9, 2015, pages 16 - 30, XP055380561, ISSN: 1936-086X
CLEMENTE-CASARES, X. ET AL.: "Expanding Antigen-Specific regulatory Networks to Treat Autoimmuity", NATURE, vol. 530, 2016, pages 434 - 440, XP055380552, ISSN: 1476-4687

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