Title:
BENZYL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/078295
Kind Code:
A1
Abstract:
Provided is a protecting reagent which can undergo deprotection in high yield even under acidic conditions in organic syntheses, e.g., peptide synthesis, and which enables high-purity products to be obtained.
The protecting reagent is a benzyl compound represented by formula (I), which has only one hydroxy group substituted by an organic group comprising an aliphatic hydrocarbon group and having 14 or more carbon atoms in total.
[In formula (I), Y represents a hydroxy group or -NHR (R represents a hydrogen atom, an alkyl, or an aralkyl); Ra represents an organic group comprising an aliphatic hydrocarbon group, the total number of carbon atoms of the organic group being 14 or more; the n Rbs each independently represents a C1-6 alkoxy, a halogen atom, or a C1-6 alkyl optionally substituted by one or more halogen atoms; and n is an integer of 0-4.]
Inventors:
TAKAHASHI DAISUKE (JP)
Application Number:
PCT/JP2010/073251
Publication Date:
June 30, 2011
Filing Date:
December 22, 2010
Export Citation:
Assignee:
AJINOMOTO KK (JP)
TAKAHASHI DAISUKE (JP)
TAKAHASHI DAISUKE (JP)
International Classes:
C07C43/23; C07C217/64; C07K1/06
Domestic Patent References:
| WO2006104166A1 | 2006-10-05 | |||
| WO2007034812A1 | 2007-03-29 | |||
| WO2007122847A1 | 2007-11-01 |
Foreign References:
| JPS6061515A | 1985-04-09 | |||
| JPH05213877A | 1993-08-24 | |||
| US2477850A | 1949-08-02 | |||
| JPH09507846A | 1997-08-12 | |||
| GB969921A | 1964-09-16 | |||
| JP2000044493A | 2000-02-15 | |||
| JP2009296366A | 2009-12-17 |
Other References:
PERCEC VIRGIL ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, 23 April 2004 (2004-04-23), pages 6078 - 6094, XP008165878
BULL. CHEM. SOC. JPN., vol. 74, 2001, pages 733 - 738
See also references of EP 2518041A4
BULL. CHEM. SOC. JPN., vol. 74, 2001, pages 733 - 738
See also references of EP 2518041A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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