Title:
BRAIN ACTIVITY ANALYSIS DEVICE, BRAIN ACTIVITY ANALYSIS METHOD, PROGRAM, AND BIOMARKER DEVICE
Document Type and Number:
WIPO Patent Application WO/2017/090590
Kind Code:
A1
Abstract:
[Problem] To provide a brain activity analysis method for achieving a biomarker by functional neuroimaging for neurological and psychiatric disorders. [Solution] A correlation matrix of the degree of activity among predetermined brain regions is derived from resting-state functional connectivity MRI data measured in a healthy group and a patient group. By regularized canonical correlation analysis (SCCA) for the correlation matrix and an attribute of a subject including a diagnostic label of the subject, elements of the correlation matrix connecting with a canonical variable corresponding only to the diagnostic label are extracted. With respect to a first union of the elements of the correlation matrix obtained by feature extraction of the regularized canonical correlation analysis, a second union of the elements of the correlation matrix is extracted by sparse logistic regression (SLR) by leave-one-out cross-validation. With respect to the second union, a discriminator is created by discriminant analysis by the sparse logistic regression.
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Inventors:
LISI GIUSEPPE (JP)
MORIMOTO JUN (JP)
KAWATO MITSUO (JP)
YAHATA NORIAKI (JP)
MORIMOTO JUN (JP)
KAWATO MITSUO (JP)
YAHATA NORIAKI (JP)
Application Number:
PCT/JP2016/084567
Publication Date:
June 01, 2017
Filing Date:
November 22, 2016
Export Citation:
Assignee:
ADVANCED TELECOMMUNICATIONS RES INST INT (JP)
International Classes:
A61B5/055
Foreign References:
| JP2015062817A | 2015-04-09 | |||
| US20150248615A1 | 2015-09-03 | |||
| JP2013218725A | 2013-10-24 | |||
| JP2014084567A | 2014-05-12 |
Other References:
VINZENZ H. SCHOFELDER: "Sparse regularized regression identifies behaviorally-relevant stimulus features from psychophysical data", THE JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, vol. 131, no. 5, May 2012 (2012-05-01), pages 3953 - 3969, XP012160197
YI-OU LI ET AL.: "Group Study of Simulated Driving fMRI Data by Multiset Canonical Correlation Analysis", JOURNAL OF SIGNAL PROCESSING SYSTEMS, vol. 68, June 2012 (2012-06-01), pages 31 - 48, XP055386498
See also references of EP 3381361A4
YI-OU LI ET AL.: "Group Study of Simulated Driving fMRI Data by Multiset Canonical Correlation Analysis", JOURNAL OF SIGNAL PROCESSING SYSTEMS, vol. 68, June 2012 (2012-06-01), pages 31 - 48, XP055386498
See also references of EP 3381361A4
Attorney, Agent or Firm:
SHIMIZU, Satoshi (JP)
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