Title:
CARRIER, COMPLEX, PHARMACEUTICAL COMPOSITION, AND DIAGNOSTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2024/048644
Kind Code:
A1
Abstract:
This carrier for delivering a target substance to MUC6 expression-negative cancer tissues contains a molecule having the activity of binding to mannose. The cancer tissues may be MUC6 expression-negative gastric cancer tissues arising from MUC6 gene mutations, intestinal-type gastric cancer, or gastric cancer that is negative for the expression of MUC5AC, MUC6, MUC2, and CD10. The molecule having the activity of binding to mannose may be a saccharide-binding protein.
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Inventors:
HAYAKAWA YOKU (JP)
ARAI JUNYA (JP)
TATENO HIROAKI (JP)
ARAI JUNYA (JP)
TATENO HIROAKI (JP)
Application Number:
PCT/JP2023/031486
Publication Date:
March 07, 2024
Filing Date:
August 30, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
AIST (JP)
AIST (JP)
International Classes:
A61K47/62; A61K45/00; A61P35/00; C12Q1/6876; G01N33/53
Domestic Patent References:
| WO2021193199A1 | 2021-09-30 |
Foreign References:
| JP2010150187A | 2010-07-08 |
Other References:
LLOYD M. G., LIU D., LEGENDRE M., MARKOVITZ D. M., MOFFAT J. F.: "H84T BanLec has broad spectrum antiviral activity against human herpesviruses in cells, skin, and mice", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 12, no. 1, 31 January 2022 (2022-01-31), US , pages 1641, XP093145602, ISSN: 2045-2322, DOI: 10.1038/s41598-022-05580-6
ARAI, JUNYA ET AL. : "J14-4-4 Lectin Drug Conjugate Therapy for Gastric Cancer with MUC6 Mutation", THE 80TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION; YOKOHAMA, JAPAN; 2021 SEP 30 ‐ OCT 2, vol. 80, 1 January 2021 (2021-01-01), pages 229, XP009553549
ARAI, JUNYA; HAYAKAWA, YOKU; SUZUKI, NOBUMI; HATA, MASAHIRO; TSUBOI, MAYO; FUJISHIRO, MITSUHIRO: "Loss of MUC6 drives gastric carcinogenesis via disruption of proteostasis and activation of oncogenic pathways", GASTROENTEROLOGY, vol. 162, no. 7, Suppl., 1 May 2022 (2022-05-01), US , pages S - 231, XP009553542, ISSN: 0016-5085, DOI: 10.1016/S0016-5085(22)60554-7
MCKENNA, MARY KATHRYN; BRENNER, DANIEL; BRENNER, BENJAMIN; WATANABE, NORIHIRO; BONIFANT, CHALLICE; MARKOVITZ, DAVID; BRENNER, MALC: "Targeting tumors and the tumor microenvironment with banana lectin expressing T cells", MOLECULAR THERAPY, vol. 30, no. 4, Suppl. 1, 2 April 2022 (2022-04-02), US , pages 579, XP009553545, ISSN: 1525-0016
ARAI, JUNYA ET AL. : "J14-4-4 Lectin Drug Conjugate Therapy for Gastric Cancer with MUC6 Mutation", THE 80TH ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION; YOKOHAMA, JAPAN; 2021 SEP 30 ‐ OCT 2, vol. 80, 1 January 2021 (2021-01-01), pages 229, XP009553549
ARAI, JUNYA; HAYAKAWA, YOKU; SUZUKI, NOBUMI; HATA, MASAHIRO; TSUBOI, MAYO; FUJISHIRO, MITSUHIRO: "Loss of MUC6 drives gastric carcinogenesis via disruption of proteostasis and activation of oncogenic pathways", GASTROENTEROLOGY, vol. 162, no. 7, Suppl., 1 May 2022 (2022-05-01), US , pages S - 231, XP009553542, ISSN: 0016-5085, DOI: 10.1016/S0016-5085(22)60554-7
MCKENNA, MARY KATHRYN; BRENNER, DANIEL; BRENNER, BENJAMIN; WATANABE, NORIHIRO; BONIFANT, CHALLICE; MARKOVITZ, DAVID; BRENNER, MALC: "Targeting tumors and the tumor microenvironment with banana lectin expressing T cells", MOLECULAR THERAPY, vol. 30, no. 4, Suppl. 1, 2 April 2022 (2022-04-02), US , pages 579, XP009553545, ISSN: 1525-0016
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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