CGRP RECEPTOR ANTAGONISTS - MERCK & CO INC

Title:

CGRP RECEPTOR ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO2006044449

Kind Code:

A3

Abstract:

Compounds of Formula (I) and Formula (II) (where variables R¹, R², R⁴, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

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Inventors:

PAONE DANIEL V (US)
SHAW ANTHONY W (US)
POTTEIGER CRAIG M (US)

Application Number:

PCT/US2005/036659

Publication Date:

November 23, 2006

Filing Date:

October 12, 2005

Export Citation:

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Assignee:

MERCK & CO INC (US)
PAONE DANIEL V (US)
SHAW ANTHONY W (US)
POTTEIGER CRAIG M (US)

International Classes:

A61K31/55; A61P25/00; C07D401/00; C07D487/00

Domestic Patent References:

WO2004092166A2

2004-10-28

Other References: