Title:
CHARGED COMPOSITE FILM MATERIAL WITH HIGH OSTEOGENIC ACTIVITY, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/016481
Kind Code:
A1
Abstract:
Disclosed is a charged composite film material with high osteogenic activity, a method for preparing same, and use thereof. The charged composite film with high osteogenic activity provided by the present invention consists of an inorganic filler and a high-molecular-weight polymer. The inorganic filler is titanium dioxide nanoparticles with particle size in the range of 50-150 nm. The doping amount of the inorganic filler is 1-10 wt%. The organic polymer is a polyvinylidene fluoride-based polymer. The composite film material provided by the present invention has high electrical polarization intensity and excellent piezoelectric properties, thus having good electrical activity, biological safety, and high osteogenic activity for promoting bone repair.
Inventors:
ZHANG XUEHUI (CN)
DENG XULIANG (CN)
SUN XIAOWEN (CN)
DENG XULIANG (CN)
SUN XIAOWEN (CN)
Application Number:
PCT/CN2022/123832
Publication Date:
January 25, 2024
Filing Date:
October 08, 2022
Export Citation:
Assignee:
UNIV PEKING SCHOOL STOMATOLOGY (CN)
International Classes:
A61L15/18; A61L27/34; A61L15/24; A61L15/42; A61L27/30; A61L27/50
Foreign References:
| CN114904054A | 2022-08-16 | |||
| CN107233625A | 2017-10-10 | |||
| CN1916069A | 2007-02-21 | |||
| CN114028609A | 2022-02-11 | |||
| JPS62212312A | 1987-09-18 | |||
| CN112791231A | 2021-05-14 |
Other References:
KIM, K.M. KO, J.M. PARK, N.-G. RYU, K.S. CHANG, S.H.: "Characterization of poly(vinylidenefluoride-co-hexafluoropropylene)-based polymer electrolyte filled with rutile TiO"2 nanoparticles", SOLID STATE IONICS, NORTH HOLLAND PUB. COMPANY. AMSTERDAM; NL, NL, vol. 161, no. 1-2, 1 July 2003 (2003-07-01), NL , pages 121 - 131, XP004448192, ISSN: 0167-2738, DOI: 10.1016/S0167-2738(03)00211-X
ANITHA AUGUSTINE ET AL.: "Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, vol. 30, 14 August 2019 (2019-08-14), XP036868156, DOI: 10.1007/s10856-019-6300-4
ANSARIZADEH MOHAMADHASAN, HADDADI SEYYED ARASH, AMINI MAJED, HASANY MASOUD, RAMAZANI SAADATABADI AHMAD: "Sustained release of CIP from TiO 2 ‐PVDF/starch nanocomposite mats with potential application in wound dressing", JOURNAL OF APPLIED POLYMER SCIENCE, JOHN WILEY & SONS, INC., US, vol. 137, no. 30, 10 August 2020 (2020-08-10), US , XP093130323, ISSN: 0021-8995, DOI: 10.1002/app.48916
AN NINGLI; FANG CHANGQING: "The Study on Electrical Properties of The PVDF/TiO2 Nano-Composite Film", XI'AN-LIGONG-DAXUE-XUEBAO = JOURNAL OF XI'AN UNIVERSITY OF TECHNOLOGY, vol. 30, no. 3, 30 September 2014 (2014-09-30), pages 288 - 292, XP009552012, ISSN: 1006-4710
ANITHA AUGUSTINE ET AL.: "Development of titanium dioxide nanowire incorporated poly(vinylidene fluoride–trifluoroethylene) scaffolds for bone tissue engineering applications", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, vol. 30, 14 August 2019 (2019-08-14), XP036868156, DOI: 10.1007/s10856-019-6300-4
ANSARIZADEH MOHAMADHASAN, HADDADI SEYYED ARASH, AMINI MAJED, HASANY MASOUD, RAMAZANI SAADATABADI AHMAD: "Sustained release of CIP from TiO 2 ‐PVDF/starch nanocomposite mats with potential application in wound dressing", JOURNAL OF APPLIED POLYMER SCIENCE, JOHN WILEY & SONS, INC., US, vol. 137, no. 30, 10 August 2020 (2020-08-10), US , XP093130323, ISSN: 0021-8995, DOI: 10.1002/app.48916
AN NINGLI; FANG CHANGQING: "The Study on Electrical Properties of The PVDF/TiO2 Nano-Composite Film", XI'AN-LIGONG-DAXUE-XUEBAO = JOURNAL OF XI'AN UNIVERSITY OF TECHNOLOGY, vol. 30, no. 3, 30 September 2014 (2014-09-30), pages 288 - 292, XP009552012, ISSN: 1006-4710
Attorney, Agent or Firm:
BEIJING ZERORICH IP FIRM (CN)
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