Title:
CHIMERIC L. MONOCYTOGENS IN1B PROTEIN
Document Type and Number:
WIPO Patent Application WO/2010/071769
Kind Code:
A3
Abstract:
The invention relates to chimeric proteins having a (i) first amino acid sequence, (ii) a linker peptide, and (iii) monomer or tandem dimer of one or more domains of In1B protein (e.g., amino acids 36 to 321 of In1B). The first amino acid sequence of the chimeric protein can be the N-terminal hairpin loop of HGF. The chimeric protein may be capable of activating p42/p44 MAPK and Akt. The invention also encompasses nucleic acids and vectors encoding the chimeric protein. In addition, the invention encompasses methods of treating skin injury, lung injury, and ischemic disease by administering a pharmaceutically effective amount of a composition containing the chimeric protein.
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Inventors:
DAY REGINA M (US)
OGNOON MUNGUNSUKH (US)
LEE YOUNG H (US)
OGNOON MUNGUNSUKH (US)
LEE YOUNG H (US)
Application Number:
PCT/US2009/067854
Publication Date:
November 04, 2010
Filing Date:
December 14, 2009
Export Citation:
Assignee:
JACKSON H M FOUND MILITARY MED (US)
DAY REGINA M (US)
OGNOON MUNGUNSUKH (US)
LEE YOUNG H (US)
DAY REGINA M (US)
OGNOON MUNGUNSUKH (US)
LEE YOUNG H (US)
International Classes:
C07K19/00; A61K38/18; A61P17/02; C12N15/62; C12N15/63
Foreign References:
| US20050281783A1 | 2005-12-22 |
Other References:
ANJU CHATTERJI, ET AL.: "Chemical Conjugation of Heterologous Proteins on the Surface of Cowpea Mosaic Virus", BIOCONJUGATE CHEM., vol. 15, no. 4, 1 July 2004 (2004-07-01), pages 807 - 813
MICHAEL MARINO, ET AL.: "Structure of the InlB Leucine-Rich Repeats, a Domain that Triggers Host Cell Invasion by the Bacterial Pathogen L. monocytogenes", MOLECULAR CELL, vol. 4, December 1999 (1999-12-01), pages 1063 - 1072
M. GRACIELA PUCCIARELLI, ET AL.: "Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis", PROTEOMICS, vol. 5, no. 18, 18 December 2005 (2005-12-18), pages 4808 - 4817
SANDRA SOUSA, ET AL.: "Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells", J CELL SCI., vol. 117, no. 10, 15 April 2004 (2004-04-15), pages 2121 - 2130
MICHAEL MARINO, ET AL.: "Structure of the InlB Leucine-Rich Repeats, a Domain that Triggers Host Cell Invasion by the Bacterial Pathogen L. monocytogenes", MOLECULAR CELL, vol. 4, December 1999 (1999-12-01), pages 1063 - 1072
M. GRACIELA PUCCIARELLI, ET AL.: "Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis", PROTEOMICS, vol. 5, no. 18, 18 December 2005 (2005-12-18), pages 4808 - 4817
SANDRA SOUSA, ET AL.: "Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells", J CELL SCI., vol. 117, no. 10, 15 April 2004 (2004-04-15), pages 2121 - 2130
Attorney, Agent or Firm:
SMYTH, Robert (Lewis & Bockius LLP1111 Pennsylvania Avenue, N, Washington DC, US)
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