Title:
CHROMONE DERIVATIVE HAVING OSTEOGENESIS PROMOTING EFFECT
Document Type and Number:
WIPO Patent Application WO/2013/111850
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound or a pharmacologically acceptable salt thereof, said compound being to be used for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture and preventing or treating diseases relating to bone metabolism, or for promoting healing in bone diseases such as bone fracture, bone defect or osteoarthritis in the field of plastic surgery and treating periodontal disease or stabilizing artificial tooth roots in the field of dentistry. Provided is a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. The meanings of the substituents in formula (I) are as follows: R1 represents a halogen atom, etc.; R2 represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; and A represents a heterocyclic group, etc.
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Inventors:
KAWAKAMI KATSUHIRO (JP)
KIHO TOSHIHIRO (JP)
TENGEIJI ATSUSHI (JP)
GOTANDA KENTOKU (JP)
AOKI KAZUMASA (JP)
YANO KAZUKI (JP)
KIHO TOSHIHIRO (JP)
TENGEIJI ATSUSHI (JP)
GOTANDA KENTOKU (JP)
AOKI KAZUMASA (JP)
YANO KAZUKI (JP)
Application Number:
PCT/JP2013/051576
Publication Date:
August 01, 2013
Filing Date:
January 25, 2013
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C07D311/22; A61K31/397; A61K31/4025; A61K31/453; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61K31/5377; A61P19/08; A61P19/10; C07D405/04; C07D405/14; C07D417/14
Domestic Patent References:
| WO1991019707A2 | 1991-12-26 | |||
| WO1990006921A1 | 1990-06-28 | |||
| WO2001053266A1 | 2001-07-26 | |||
| WO2007099432A2 | 2007-09-07 | |||
| WO2009101959A1 | 2009-08-20 |
Foreign References:
| JP2004075677A | 2004-03-11 |
Other References:
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ROMA,G. ET AL.: "Coumarin, chromone, and 4(3H)- pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 1, 2003, pages 123 - 138, XP055155133
VENKATESAN,P. ET AL.: "Synthesis of substituted flavone derivatives as potent antimicrobial agents", BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol. 25, no. 3, 2011, pages 419 - 425, XP055155136
RAMU,M. ET AL.: "Facile synthesis of 8-(lH-benzo [d]imidazol-2-yl)-7-methoxyflavones", INTERNATIONAL JOURNAL OF PHARMACY AND TECHNOLOGY, vol. 3, no. 4, 2011, pages 3490 - 3498, XP055158741
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NEW ENG. J. MED., vol. 314, 1986, pages 1976
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PROG. MED., vol. 5, 1985, pages 2157 - 2161
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS, INC.
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
J. JACQUES ET AL.: "Enantiomers, Racemates and Resolution", JOHN WILEY AND SONS, INC.
ROMA,G. ET AL.: "Coumarin, chromone, and 4(3H)- pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 1, 2003, pages 123 - 138, XP055155133
VENKATESAN,P. ET AL.: "Synthesis of substituted flavone derivatives as potent antimicrobial agents", BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol. 25, no. 3, 2011, pages 419 - 425, XP055155136
RAMU,M. ET AL.: "Facile synthesis of 8-(lH-benzo [d]imidazol-2-yl)-7-methoxyflavones", INTERNATIONAL JOURNAL OF PHARMACY AND TECHNOLOGY, vol. 3, no. 4, 2011, pages 3490 - 3498, XP055158741
DATABASE REGISTRY [online] 25 March 2013 (2013-03-25), XP055185548, accession no. STN Database accession no. 1177484-76-2
NEW ENG. J. MED., vol. 314, 1986, pages 1976
T.W. GREENE; P.G. WUTS: "Protective Groups in Organic Synthesis", 1999
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS, INC.
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
J. JACQUES ET AL.: "Enantiomers, Racemates and Resolution", JOHN WILEY AND SONS, INC.
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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