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Title:
COLLAGEN PRODUCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/073060
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a collagen production inhibitor, which comprises as an active ingredient a low-molecular compound having an effect of effectively inhibiting (preventing) collagen production, and a prophylactic or therapeutic agent for skin fibrotic diseases which is capable of effectively preventing or treating skin fibrotic diseases. A preparation comprising one or more members selected from compounds represented by formulae (1) and (2) and salts thereof is used as a collagen production inhibitor or a prophylactic or therapeutic agent for skin fibrotic diseases.

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Inventors:
ISHII TOMONORI (JP)
AIBA SETSUYA (JP)
ABE TAKAAKI (JP)
KAWAGUCHI YASUSHI (JP)
HIGUCHI TOMOAKI (JP)
HAYASHI KENICHIRO (JP)
Application Number:
PCT/JP2016/004714
Publication Date:
May 04, 2017
Filing Date:
October 27, 2016
Export Citation:
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Assignee:
UNIV TOHOKU (JP)
KAKE EDUCATIONAL INST (JP)
TOKYO WOMEN'S MEDICAL UNIV (JP)
International Classes:
A61K31/405; A61P17/00; A61P17/06
Foreign References:
JP2015164950A2015-09-17
JP2002504541A2002-02-12
JP2009528290A2009-08-06
JPH05502222A1993-04-22
JP2006516982A2006-07-13
JP2015189670A2015-11-02
Other References:
SUZUKI, T ET AL.: "Mitochonic acid 5 (MA-5), a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases.", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 6, no. 3, 23 June 2015 (2015-06-23), pages 225 - 232, XP055379193
YUSHO ISHII ET AL.: "Shinki Indole Kagobutsu MA-35 wa Kyohisho Kanja Hifu Sen'iga Saibo no Collagen Sansei o Yokusei suru", JAPAN COLLEGE OF RHEUMATOLOGY SOKAI · GAKUJUTSU SHUKAI PROGRAM · SHOROKUSHU, vol. 60 th, March 2016 (2016-03-01), pages 345
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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