Title:
COMPLEX CAPABLE OF INHIBITING GENETIC FUNCTION IN EXOSOME, AND CANCER PROLIFERATION AND/OR METASTASIS SUPPRESSOR
Document Type and Number:
WIPO Patent Application WO/2017/142083
Kind Code:
A1
Abstract:
The present invention provides a complex comprising an antibody that targets an exosome surface antigen or an antibody fragment of the antibody and a suppressor of a gene or an expression product of the gene, wherein the antibody or the antibody fragment and the suppressor of the gene or the expression product of the gene are covalently bound to each other directly or through a linker or are non-covalently bound to each other.
Inventors:
YAMAYOSHI ASAKO (JP)
MURAKAMI AKIRA (JP)
ASHIHARA EISHI (JP)
KOBORI AKIO (JP)
MURAKAMI AKIRA (JP)
ASHIHARA EISHI (JP)
KOBORI AKIO (JP)
Application Number:
PCT/JP2017/005994
Publication Date:
August 24, 2017
Filing Date:
February 17, 2017
Export Citation:
Assignee:
UNIV KYOTO (JP)
KYOTO PHARMACEUTICAL UNIV (JP)
KYOTO PHARMACEUTICAL UNIV (JP)
International Classes:
A61K39/395; A61K31/7105; A61K48/00; A61P35/00; A61P35/04
Domestic Patent References:
| WO2014167969A1 | 2014-10-16 | |||
| WO2013099925A1 | 2013-07-04 |
Other References:
XIONG B ET AL.: "MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 42, no. 1, 2013, pages 219 - 228, XP055410573, ISSN: 1019-6439
FIORI ME ET AL.: "Antitumor effect of miR-197 targeting in p53 wild-type lung cancer", CELL DEATH AND DIFFERENTIATION, vol. 21, no. 5, 2014, pages 774 - 782, XP055410574, ISSN: 1350-9047
See also references of EP 3417877A4
FIORI ME ET AL.: "Antitumor effect of miR-197 targeting in p53 wild-type lung cancer", CELL DEATH AND DIFFERENTIATION, vol. 21, no. 5, 2014, pages 774 - 782, XP055410574, ISSN: 1350-9047
See also references of EP 3417877A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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