Title:
COMPOSITION FOR INHIBITING METASTASIS OF LIVER CANCER, CONTAINING DIOSPYROS KAKI LEAF EXTRACT
Document Type and Number:
WIPO Patent Application WO/2020/022688
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting the metastasis of liver cancer, containing a Diospyros kaki leaf extract and, more particularly, to: a pharmaceutical composition for inhibiting the metastasis of liver cancer, containing a Diospyros kaki leaf extract; a method for inhibiting the metastasis of liver cancer, comprising a step of administering the composition to a subject; and an anticancer adjuvant composition, a quasi-drug composition and a health functional food, which are for inhibiting the metastasis of liver cancer and contain a Diospyros kaki leaf extract. A Diospyros kaki leaf extract according to the present invention has low cytotoxicity, enables inhibition of invasion and migration properties of liver cancer cells and enables inhibition of the metastasis of liver cancer cells by means of the inhibition of metastasis-associated signaling system, thereby being effectively usable as a pharmaceutical composition, an anticancer adjuvant composition, a quasi-drug composition and a health functional food composition for inhibiting the metastasis of liver cancer.
Inventors:
KIM YOUNG-JOO (KR)
JUNG SANG HOON (KR)
PARK YOUNG NYUN (KR)
KIM KYUNG A (KR)
KWON HAK CHEOL (KR)
LEE JUNG HWAN (KR)
HUH GYUWON (KR)
YOO JEONG EUN (KR)
JEON YOUNGSIC (KR)
JUNG SANG HOON (KR)
PARK YOUNG NYUN (KR)
KIM KYUNG A (KR)
KWON HAK CHEOL (KR)
LEE JUNG HWAN (KR)
HUH GYUWON (KR)
YOO JEONG EUN (KR)
JEON YOUNGSIC (KR)
Application Number:
PCT/KR2019/008765
Publication Date:
January 30, 2020
Filing Date:
July 16, 2019
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
A61K36/44; A23L33/105; A61P35/04
Foreign References:
| KR101468015B1 | 2014-12-03 | |||
| KR20050043130A | 2005-05-11 | |||
| CN1274599A | 2000-11-29 | |||
| KR101686777B1 | 2016-12-15 |
Other References:
CHEN, L.: "Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H 22 liver tumor-bearing mice", SCIENTIFIC REPORTS, vol. 10523, 12 July 2018 (2018-07-12), pages 1 - 11, XP055681810, DOI: 10.1038/s41598-018-28440-8
Attorney, Agent or Firm:
SON, Min (KR)
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