Title:
COMPOSITION FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2023/140309
Kind Code:
A1
Abstract:
[Problem] To elucidate the mechanism of an anti-tumor effect of a ketogenic diet therapy to discover a novel cancer treatment method. [Solution] Provided is a composition for treating cancer, the composition comprising a ketogenic diet therapy composition and is used in combination with an inflammatory cytokine inhibitor. Also provided is a novel cancer immunotherapy comprising a combination of the administration of an inflammatory cytokine inhibitor and a ketogenic diet therapy. The ketogenic diet therapy composition is a composition containing a fat in an amount of 55% or more. The inflammatory cytokine inhibitor is preferably an IL-1 inhibitor, an IL-6 inhibitor or a TNF-α inhibitor. When used in combination with the inflammatory cytokine inhibitor, the anti-tumor effect of the ketogenic diet therapy is enhanced.
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Inventors:
HAGIHARA KEISUKE (JP)
NAKAMURA KENTAROU (JP)
ASHIDA KINYA (JP)
MANJI AIKO (JP)
NAKAMURA KENTAROU (JP)
ASHIDA KINYA (JP)
MANJI AIKO (JP)
Application Number:
PCT/JP2023/001448
Publication Date:
July 27, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
MEIJI HOLDINGS CO LTD (JP)
MEIJI HOLDINGS CO LTD (JP)
International Classes:
A61K45/00; A61K31/23; A61K39/395; A61K45/06; A61P35/00; A61P43/00; A23L33/115
Domestic Patent References:
| WO2021006276A1 | 2021-01-14 |
Foreign References:
| JP2016514135A | 2016-05-19 |
Other References:
TATSUYA AKIZUKI, MASATO MINABE: "Anti-inflammatory effect of curcumin in periodontitis", NIHON SHISHUBYO GAKKAI KAISHI (JOURNAL OF THE JAPANESE SOCIETY OF PERIODONTOLOGY), vol. 57, no. 2, 28 June 2015 (2015-06-28), pages 70 - 75, XP093079244, ISSN: 0385-0110, DOI: 10.2329/perio.57.70
NAKAMURA K, TONOUCHI H, SASAYAMA A, ASHIDA K: "A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice", NUTRIENTS, vol. 10, no. 2, 14 February 2018 (2018-02-14), pages 1 - 10, XP002793333, DOI: 10.3390/nu10020206
CHARLES A. DINARELLO: "Why not treat human cancer with interleukin-1 blockade?", CANCER AND METASTASIS REVIEWS, vol. 29, no. 2, 28 April 2010 (2010-04-28), Do , pages 317 - 329, XP019815068, ISSN: 1573-7233
NAKAMURA K, TONOUCHI H, SASAYAMA A, ASHIDA K: "A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice", NUTRIENTS, vol. 10, no. 2, 14 February 2018 (2018-02-14), pages 1 - 10, XP002793333, DOI: 10.3390/nu10020206
CHARLES A. DINARELLO: "Why not treat human cancer with interleukin-1 blockade?", CANCER AND METASTASIS REVIEWS, vol. 29, no. 2, 28 April 2010 (2010-04-28), Do , pages 317 - 329, XP019815068, ISSN: 1573-7233
Attorney, Agent or Firm:
SHOJI Takashi et al. (JP)
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