Title:
COMPOUND CONTAINING BIS(AZANYLYLIDENE) SULFONYL STRUCTURE AND USE THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2023/116774
Kind Code:
A1
Abstract:
A compound containing a bis(azanylylidene) sulfonyl structure of formula (I) as a PKR agonist and/or USP9X inhibitor, which can be used for treating related diseases mediated and regulated by PKR and USP9X, wherein the related diseases comprise, but are not limited to: sickle-cell anemia, β-thalassemia, hereditary non-spherocytic hemolytic anemia, hemolytic anemia, hereditary spherocytosis, hereditary elliptocytosis, abetalipoproteinemia, paroxysmal nocturnal hemoglobinuria, acquired hemolytic anemia, congenital anemia, anemia of chronic diseases, colorectal cancer, kidney cancer, pancreatic cancer, breast cancer, lung cancer, esophageal cancer, melanoma, lymphoma, glioblastoma, or multiple myeloma.
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Inventors:
LI JIANZONG (CN)
WANG ZAO (CN)
ZHAO SHUCHUN (CN)
SHAO TAO (CN)
ZHOU RUIJIE (CN)
WANG JING (CN)
HU XIAO (CN)
WANG YEYE (CN)
ZHANG XIAODONG (CN)
TANG JUN (CN)
TANG YUANQING (CN)
WANG ZAO (CN)
ZHAO SHUCHUN (CN)
SHAO TAO (CN)
ZHOU RUIJIE (CN)
WANG JING (CN)
HU XIAO (CN)
WANG YEYE (CN)
ZHANG XIAODONG (CN)
TANG JUN (CN)
TANG YUANQING (CN)
Application Number:
PCT/CN2022/140731
Publication Date:
June 29, 2023
Filing Date:
December 21, 2022
Export Citation:
Assignee:
SCINNOHUB PHARMACEUTICAL CO LTD (CN)
CHENGDU BRILLIANT PHARMACEUTICAL CO LTD (CN)
CHENGDU BRILLIANT PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/397; C07D403/04; A61P35/00; C07D205/02
Domestic Patent References:
| WO2018175474A1 | 2018-09-27 | |||
| WO2020061261A1 | 2020-03-26 | |||
| WO2020061255A1 | 2020-03-26 |
Foreign References:
| US20200085798A1 | 2020-03-19 |
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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