Title:
CYCLIN-DEPENDENT KINASE 9 INHIBITOR IN SOLID FORM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/257965
Kind Code:
A1
Abstract:
Provided are a compound of formula (A) in a solid form, in particular in a crystalline form, a specific crystal form, and the use thereof. The compound represented by formula (A) has excellent cyclin-dependent kinase 9 in vitro inhibitory activity, excellent tumor cell in vitro inhibitory activity, excellent in vivo antitumor activity, and better safety, and the obtained crystal form of the compound represented by formula (A) has the characteristics of good crystallinity, low hygroscopicity, and good stability, and has good druggable potential.
Inventors:
LI ZHIHUAI (CN)
ZHAO LIANGLIANG (CN)
ZHAO JIE (CN)
HAO HONGRU (CN)
DAO SHUO (CN)
CAO ZEFENG (CN)
HE YING (CN)
ZHAO LIANGLIANG (CN)
ZHAO JIE (CN)
HAO HONGRU (CN)
DAO SHUO (CN)
CAO ZEFENG (CN)
HE YING (CN)
Application Number:
PCT/CN2022/097623
Publication Date:
December 15, 2022
Filing Date:
June 08, 2022
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)
International Classes:
C07D213/75; A61K31/44; A61K31/4418; A61K31/4545; A61P29/00; A61P35/00
Domestic Patent References:
| WO2021115335A1 | 2021-06-17 |
Foreign References:
| CN102834380A | 2012-12-19 | |||
| CN102498107A | 2012-06-13 | |||
| CN102471310A | 2012-05-23 | |||
| CN102482265A | 2012-05-30 |
Other References:
CIDADO JUSTIN, BOIKO SCOTT, PROIA THERESA, FERGUSON DOUGLAS, CRISCIONE STEVEN W., SAN MARTIN MARYANN, POP-DAMKOV PETAR, SU NANCY, : "AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 26, no. 4, 15 February 2020 (2020-02-15), US, pages 922 - 934, XP093013476, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-19-1853
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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