Title:
ELECTRON ACCEPTOR, AND REAGENT LAYER AND SENSOR EACH USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/171473
Kind Code:
A1
Abstract:
The present invention provides a redox polymer or a redox mediator constituting the redox polymer, each of which is used for forming an electrochemical sensor capable of being suitably used for a measurement for a long period (a continuous monitoring) and having excellent stability. The redox mediator provided by the present invention is a phenothiazine-based compound having a hydrophilic moiety introduced therein and represented by general formula (2A) or (2B), and the redox polymer provided by the present invention is a polymer-binding phenothiazine-based compound represented by general formula (3A) or (3B). In the formulae, R9 and R10 each independently represent a substituent or either one of these residues represents a substituent and the other represents a hydrogen atom; R(L)1, R(L)2 and R(L)4 to R(L)8 each independently represent a specific group or atom; (QP)1, (QP)2 and (QP)4 to (QP)8 are present when each of the corresponding residues R(L)1, R(L)2 and R(L)4 to R(L)8 is a specific group, and each independently represent a polymeric structure derived from a high-molecular-weight polymer.
Inventors:
HANEDA KEIGO
TAKAHARA YOSHIFUMI
TAKAHARA YOSHIFUMI
Application Number:
PCT/JP2023/007472
Publication Date:
September 14, 2023
Filing Date:
March 01, 2023
Export Citation:
Assignee:
PHC HOLDINGS CORP (JP)
International Classes:
C07D279/18; G01N27/327
Domestic Patent References:
| WO2022043491A2 | 2022-03-03 |
Other References:
MURRAY JAMES, NOWAK DOMINIKA, PUKENAS LAURYNAS, AZHAR RIZUAN, GUILLORIT MATHIEU, WÄLTI CHRISTOPH, CRITCHLEY KEVIN, JOHNSON STEVEN,: "Solid phase synthesis of functionalised SAM-forming alkanethiol–oligoethyleneglycols", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 2, no. 24, 1 January 2014 (2014-01-01), GB , pages 3741 - 3744, XP055934217, ISSN: 2050-750X, DOI: 10.1039/C4TB00573B
KOUTSOUMPELI ELENI, TIEDE CHRISTIAN, MURRAY JAMES, TANG ANNA, BON ROBIN S., TOMLINSON DARREN C., JOHNSON STEVEN: "Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 89, no. 5, 7 March 2017 (2017-03-07), US , pages 3051 - 3058, XP055934122, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04790
BOGUSLAVSKY L. I., ET AL.: "AMPEROMETRIC THIN FILM BIOSENSORS BASED ON GLUCOSE DEHYDROGENASE AND TOLUIDINE BLUE O AS CATALYST FOR NADH ELECTROOXIDATION.", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 10., no. 08., 1 January 1995 (1995-01-01), Amsterdam , NL , pages 693 - 704., XP000564136, ISSN: 0956-5663, DOI: 10.1016/0956-5663(95)96960-7
YETUNDE E. SORUNMU; MINDY NGUYEN; JOHN B. SAPP; WALDEMAR GORSKI; TUAN D. PHAN; XIN WEI: "Study of Factors Affecting Molecular Behaviors in Phenothiazine‐Mediated Biosensing by Electrochemical and Spectroscopic Methods", ELECTROANALYSIS, VHC PUBLISHERS, INC., US, vol. 18, no. 23, 27 November 2006 (2006-11-27), US , pages 2375 - 2380, XP071934956, ISSN: 1040-0397, DOI: 10.1002/elan.200603673
KOUTSOUMPELI ELENI, TIEDE CHRISTIAN, MURRAY JAMES, TANG ANNA, BON ROBIN S., TOMLINSON DARREN C., JOHNSON STEVEN: "Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 89, no. 5, 7 March 2017 (2017-03-07), US , pages 3051 - 3058, XP055934122, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04790
BOGUSLAVSKY L. I., ET AL.: "AMPEROMETRIC THIN FILM BIOSENSORS BASED ON GLUCOSE DEHYDROGENASE AND TOLUIDINE BLUE O AS CATALYST FOR NADH ELECTROOXIDATION.", BIOSENSORS AND BIOELECTRONICS, ELSEVIER SCIENCE LTD, UK, AMSTERDAM , NL, vol. 10., no. 08., 1 January 1995 (1995-01-01), Amsterdam , NL , pages 693 - 704., XP000564136, ISSN: 0956-5663, DOI: 10.1016/0956-5663(95)96960-7
YETUNDE E. SORUNMU; MINDY NGUYEN; JOHN B. SAPP; WALDEMAR GORSKI; TUAN D. PHAN; XIN WEI: "Study of Factors Affecting Molecular Behaviors in Phenothiazine‐Mediated Biosensing by Electrochemical and Spectroscopic Methods", ELECTROANALYSIS, VHC PUBLISHERS, INC., US, vol. 18, no. 23, 27 November 2006 (2006-11-27), US , pages 2375 - 2380, XP071934956, ISSN: 1040-0397, DOI: 10.1002/elan.200603673
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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