Title:
ENGINEERING STEM CELLS FOR CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO/2019/179400
Kind Code:
A1
Abstract:
Provided is an engineered stem cell comprising a vector with a polynucleotide comprising a nucleic acid sequence of suicide gene, a nucleic acid sequence of immune checkpoint gene and a natural cytotoxicity triggering receptor or a TNF-related apoptosis-inducing ligand, wherein the stem cell is a tumor-targeting cell. Also provided is a method for treating a cancer or enhancing intratumor immunity or enhancing immunity in tumor microenvironment in a subject, comprising administering an effective amount of the engineered stem cell.
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Inventors:
SHYU WOEI-CHERNG (CN)
LIN CHEN-HUAN (CN)
CHEN CHIEN-LIN (CN)
JENG LONG-BIN (CN)
TSAI CHANG-HAI (CN)
LEE WEI (CN)
LIN CHEN-HUAN (CN)
CHEN CHIEN-LIN (CN)
JENG LONG-BIN (CN)
TSAI CHANG-HAI (CN)
LEE WEI (CN)
Application Number:
PCT/CN2019/078555
Publication Date:
September 26, 2019
Filing Date:
March 18, 2019
Export Citation:
Assignee:
UNIV CHINA MEDICAL (CN)
International Classes:
C12N15/12; A61K35/12; C12N7/01; C12N15/861
Domestic Patent References:
| WO2016026854A2 | 2016-02-25 |
Foreign References:
| US20140369979A1 | 2014-12-18 | |||
| CN106636000A | 2017-05-10 | |||
| CN103182089A | 2013-07-03 |
Other References:
KIM, S.W. ET AL.: "Complete Regression of Metastatic Renal Cell Carcinoma by Multiple Injections of Engineered Mesenchymal Stem Cells Expressing Dodecameric TRAIL and HSV- TK", CLINICAL CANCER RESEARCH, vol. 19, no. 2, 30 November 2012 (2012-11-30), pages 415 - 427, XP055079768, doi:10.1158/1078-0432.CCR-12-1568
HENDRIKS, D. ET AL.: "Programmed Death Ligand 1 (PD-Ll)-targeted TRAIL combines PD- L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction", ONCOIMMUNOLOGY, vol. 5, no. 8, 6 July 2016 (2016-07-06), pages e1202390 - 1-e1202390-13, XP055475948
See also references of EP 3768842A4
HENDRIKS, D. ET AL.: "Programmed Death Ligand 1 (PD-Ll)-targeted TRAIL combines PD- L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction", ONCOIMMUNOLOGY, vol. 5, no. 8, 6 July 2016 (2016-07-06), pages e1202390 - 1-e1202390-13, XP055475948
See also references of EP 3768842A4
Attorney, Agent or Firm:
LEE AND LI - LEAVEN IPR AGENCY LTD. (CN)
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