Title:
FORSYTHIA SUSPENSA AND RADIX ASTRAGALI COMPOUND TRADITIONAL CHINESE MEDICINE DECOCTION-DERIVED MICRO RIBONUCLEIC ACID, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/201836
Kind Code:
A1
Abstract:
Provided are a forsythia suspensa and radix astragali compound traditional Chinese medicine decoction-derived micro ribonucleic acid and a preparation method therefor. The micro ribonucleic acid is selected from miRNAs with nucleotide sequences as shown in SEQ ID NOs. 1-15. Further provided are a miRNA QQ_159 with the nucleotide sequence as shown in SEQ ID NO. 14, comprising an artificially synthesized QQ_159, a plant QQ_159, a precursor form of the QQ_159, or a mature form of the QQ_159, use of the miRNA QQ_159 in the preparation of a drug for treating viral pneumonia caused by viral influenza and SARS-CoV-2 virus, and a pharmaceutical composition comprising the miRNA QQ_159 and a pharmaceutically acceptable carrier.
Inventors:
GU XIAOSONG (CN)
MAO SUSU (CN)
GONG LEILEI (CN)
YANG XIAOMING (CN)
WANG XINGHUI (CN)
SUN HUALIN (CN)
XU LAI (CN)
MAO SUSU (CN)
GONG LEILEI (CN)
YANG XIAOMING (CN)
WANG XINGHUI (CN)
SUN HUALIN (CN)
XU LAI (CN)
Application Number:
PCT/CN2022/094829
Publication Date:
October 26, 2023
Filing Date:
May 25, 2022
Export Citation:
Assignee:
UNIV NANTONG (CN)
International Classes:
C12N15/113; A61K31/7105; A61P11/00; A61P29/00; A61P31/14; A61P31/16; C12N15/10
Foreign References:
| CN111249299A | 2020-06-09 | |||
| CN101076592A | 2007-11-21 | |||
| CN111249390A | 2020-06-09 | |||
| US20150291962A1 | 2015-10-15 |
Other References:
DATABASE NUCLEOTIDE ANONYMOUS : "Arabidopsis thaliana microRNA MIR159", XP093106476, retrieved from NCBI
YANG XIAOMING, ZHANG YU; WANG XINGHUI; XU LINGCHI; XU LAI; GU XIAOSON: "Clinical Efficacy Analysis of Qiaoqi Granule Treating Influenza", MEDICAL JOURNAL OF COMMUNICATION, vol. 35, no. 1, 20 February 2021 (2021-02-20), pages 51 - 53, XP093106499, ISSN: 1006-2440, DOI: 10.19767/j.cnki.32-1412.2021.01.014
Z HOU, ZHEN ET AL.: "Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses", CELL RES, vol. 25, no. 1, 7 October 2014 (2014-10-07), pages 39 - 49, XP055247995, ISSN: 1748-7838, DOI: 10.1038/cr.2014.130
YANG XIAOMING, ZHANG YU; WANG XINGHUI; XU LINGCHI; XU LAI; GU XIAOSON: "Clinical Efficacy Analysis of Qiaoqi Granule Treating Influenza", MEDICAL JOURNAL OF COMMUNICATION, vol. 35, no. 1, 20 February 2021 (2021-02-20), pages 51 - 53, XP093106499, ISSN: 1006-2440, DOI: 10.19767/j.cnki.32-1412.2021.01.014
Z HOU, ZHEN ET AL.: "Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses", CELL RES, vol. 25, no. 1, 7 October 2014 (2014-10-07), pages 39 - 49, XP055247995, ISSN: 1748-7838, DOI: 10.1038/cr.2014.130
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD. (CN)
Download PDF: