FREEZE-DRIED VACCINE ADJUVANT - STATENS SERUMINSTITUT

Title:

FREEZE-DRIED VACCINE ADJUVANT

Document Type and Number:

WIPO Patent Application WO2005060330

Kind Code:

A3

Abstract:

The present invention discloses a new adjuvant component that possesses the capacity to elicit a strong and long-persisting immune response, when administered in combination with an antigenic substance even though this antigenic substance may have only poor immunogenicity per se, and which can be freeze-dried and subsequently dissolved without heating. The adjuvant of the invention comprises a quaternary amine with a halogen counter ion of the formula NR<1>R<2>R<3>R<4>-hal, wherein R<1> and R<2> independently each is a short chain alkyl group containing to 1 to 3 carbon atoms, preferably methyl groups, R<3> and R<4> independently each is an alken containing from 12 to 20 carbon atoms, preferable from 14 to 18 carbon atoms, and hal is a halogen atom.

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Inventors:

AGGER ELSE MARIE (DK)
ANDERSEN PETER (DK)

Application Number:

PCT/DK2004/000893

Publication Date:

August 04, 2005

Filing Date:

December 21, 2004

Export Citation:

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Assignee:

STATENS SERUMINSTITUT
AGGER ELSE MARIE (DK)
ANDERSEN PETER (DK)

International Classes:

A61K31/14; A61K39/04; A61K39/39; (IPC1-7): A61K39/39; A61K9/127; A61K31/14; A61K39/04

Domestic Patent References:

WO2001015726A2	2001-03-08
WO2002071944A1	2002-09-19

Foreign References:

US20030125292A1	2003-07-03
US6649170B1	2003-11-18

Other References:

HOGARTH P J ET AL: "Evaluation of adjuvants for protein vaccines against tuberculosis in guinea pigs", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 21, no. 9-10, 14 February 2003 (2003-02-14), pages 977 - 982, XP004402626, ISSN: 0264-410X
SUBCZYNSKI WITOLD K ET AL: "Effects of probucol on phase transition and fluidity of phosphatidylcholine membranes: A spin label study", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 55, no. 1, 1994, pages 1 - 11, XP002329358, ISSN: 0162-0134

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