Title:
FUSION PROTEINS CONTAINING CD47 ANTIBODIES AND CYTOKINES
Document Type and Number:
WIPO Patent Application WO/2019/091473
Kind Code:
A1
Abstract:
Provided are fusion proteins containing cytokines and novel CD47 antibodies or immunologically active fragments thereof, as well as pharmaceutical composition containing such fusion proteins that can be used for treatment of diseases mediated by CD47 or inhibition of phagocytosis or platelet aggregation. These fused proteins have low immunogenicity in humans and cause low or no level of red blood cell depletion or hemagglutination.
Inventors:
WANG ZHENGYI (CN)
CAO WEI (CN)
FANG LEI (CN)
GUO BINGSHI (CN)
CAO WEI (CN)
FANG LEI (CN)
GUO BINGSHI (CN)
Application Number:
PCT/CN2018/114975
Publication Date:
May 16, 2019
Filing Date:
November 12, 2018
Export Citation:
Assignee:
I MAB BIOPHARMA CO LTD (CN)
International Classes:
A61K39/395; C12N15/62; A61P35/00; C07K14/705; C07K16/00
Domestic Patent References:
| WO2018075857A1 | 2018-04-26 | |||
| WO2014121093A1 | 2014-08-07 | |||
| WO2016044021A1 | 2016-03-24 | |||
| WO2016024021A1 | 2016-02-18 |
Foreign References:
| CN105101997A | 2015-11-25 | |||
| CN104271757A | 2015-01-07 | |||
| CN101133083A | 2008-02-27 |
Other References:
WANG, Z.Y.: ""Abstract 5622: A novel immunocytokine fusion protein combining 1-20 tumor-targeting anti-CD47 antibody with GM-CSF cytokine for enhanced antitumor efficacy", CANCER RESEARCH, vol. 78, no. 13, 31 July 2018 (2018-07-31), pages 5622, XP009514903
YOUNG, P.A: "Antibody-cytokine fusion proteins for treatment of cancer: Engineering cytokines for improved efficacy and safety", SEMINARS IN ONCOLOGY, vol. 41, no. 5, 1 October 2015 (2015-10-01), pages 1 - 19, XP009506872
CHAO, M.P.: "The CD47-SIRPa pathway in cancer immune evasion and potential therapeutic implications", CURRENT OPINION IN IMMUNOLOGY, vol. 24, 4 February 2012 (2012-02-04), pages 225 - 232, XP055029985
See also references of EP 3541941A4
YOUNG, P.A: "Antibody-cytokine fusion proteins for treatment of cancer: Engineering cytokines for improved efficacy and safety", SEMINARS IN ONCOLOGY, vol. 41, no. 5, 1 October 2015 (2015-10-01), pages 1 - 19, XP009506872
CHAO, M.P.: "The CD47-SIRPa pathway in cancer immune evasion and potential therapeutic implications", CURRENT OPINION IN IMMUNOLOGY, vol. 24, 4 February 2012 (2012-02-04), pages 225 - 232, XP055029985
See also references of EP 3541941A4
Attorney, Agent or Firm:
BEIJING CELUE LAW FIRM (CN)
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