Title:
GENE RELATED TO THE ACTION OF ISOFLAVONES
Document Type and Number:
WIPO Patent Application WO/2011/108699
Kind Code:
A1
Abstract:
Disclosed is a gene (or product thereof), "Pap associated domain containing 5" (Papd5), identified as a gene necessary for equol to exhibit anticancer activity, for use as a biomarker for diagnosing the effectiveness, in a subject, of an anticancer substance selected from a group comprising equol, daidzein, and analogs thereof. Also disclosed is a product for detecting a biomarker using PCR, a DNA array, ELISA, a protein array, mass spectrometry, or immunochromatography. Further disclosed is a method for determining the effectiveness, in a subject, of an anticancer substance selected from a group comprising equol, daidzein, and analogs thereof. Said method includes a step for detecting the transcription or expression of Papd5 in a sample taken from the subject.
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Inventors:
TACHIBANA HIROFUMI (JP)
Application Number:
PCT/JP2011/055057
Publication Date:
September 09, 2011
Filing Date:
March 04, 2011
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
TACHIBANA HIROFUMI (JP)
TACHIBANA HIROFUMI (JP)
International Classes:
C12N15/09; C12Q1/02; C12Q1/68; A61K35/00; A61P35/00
Other References:
DATABASE GENBANK [online] 27 December 2009 (2009-12-27), WALOWSKY, C. ET AL.: "Definition: Homo sapiens PAP associated domain containing 5 (PAPD5)", retrieved from http://www.ncbi.nlm.nih.gov/ nuccore/256818779?sat=13&satkey=9230099 Database accession no. NM_001040284
WALOWSKY, C. ET AL.: "The topoisomerase- related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin.", J. BIOL. CHEM., vol. 274, no. 11, 12 March 1999 (1999-03-12), pages 7302 - 7308
L'ESPERANCE, S. ET AL.: "Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.", INT. J. ONCOL., vol. 29, no. 1, July 2006 (2006-07-01), pages 5 - 24, XP055208986, DOI: doi:10.3892/ijo.29.1.5
KOJI YAMADA ET AL.: "Hito Nyu Gan MCF-7 Saibo no Zoshoku ni Oyobosu Isoflavone no Sayo", DAIZU TANPAKUSHITSU KENKYU, vol. 3, October 2000 (2000-10-01), pages 54 - 58
SHOKO KAMAIKE ET AL.: "Equol Kanchi Idenshi: Equol no Gan Saibo Zoshoku Yokusei Sayo o Ninau Idenshi no Dotei", NIPPON NOGEI KAGAKUKAI TAIKAI KOEN YOSHISHU, vol. 2010, 5 March 2010 (2010-03-05), pages 183
WALOWSKY, C. ET AL.: "The topoisomerase- related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin.", J. BIOL. CHEM., vol. 274, no. 11, 12 March 1999 (1999-03-12), pages 7302 - 7308
L'ESPERANCE, S. ET AL.: "Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.", INT. J. ONCOL., vol. 29, no. 1, July 2006 (2006-07-01), pages 5 - 24, XP055208986, DOI: doi:10.3892/ijo.29.1.5
KOJI YAMADA ET AL.: "Hito Nyu Gan MCF-7 Saibo no Zoshoku ni Oyobosu Isoflavone no Sayo", DAIZU TANPAKUSHITSU KENKYU, vol. 3, October 2000 (2000-10-01), pages 54 - 58
SHOKO KAMAIKE ET AL.: "Equol Kanchi Idenshi: Equol no Gan Saibo Zoshoku Yokusei Sayo o Ninau Idenshi no Dotei", NIPPON NOGEI KAGAKUKAI TAIKAI KOEN YOSHISHU, vol. 2010, 5 March 2010 (2010-03-05), pages 183
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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Claims: