Title:
GENES ENCODING PROTEINS WITH PESTICIDAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO2005066349
Kind Code:
A3
Abstract:
Compositions and methods for protecting a plant from an insect pest are provided. The invention provides mutagenized nucleic acids that have been engineered to encode pesticidal polypeptides having increased resistance to proteolytic degradation by a plant protease. In particular, nucleic acid sequences encoding pesticidal polypeptides modified to comprise a proteolytic protection site that confers resistance to degradation or proteolytic inactivation by a plant protease are provided. Particular embodiments of the invention provide pesticidal polypeptide compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds. These compositions find use in methods for controlling pests, especially plant pests. Novel plant proteases, sequences encoding these proteases, and methods for their use are also provided.
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Inventors:
ABAD ANDRE (US)
DONG HUA (US)
HERRMANN RAFAEL (US)
LU ALBERT (US)
MCCUTCHEN BILLY F (US)
RICE JANET A (US)
SCHEPERS ERIC J (US)
WONG JAMES F (US)
DONG HUA (US)
HERRMANN RAFAEL (US)
LU ALBERT (US)
MCCUTCHEN BILLY F (US)
RICE JANET A (US)
SCHEPERS ERIC J (US)
WONG JAMES F (US)
Application Number:
PCT/US2004/041530
Publication Date:
October 27, 2005
Filing Date:
December 09, 2004
Export Citation:
Assignee:
PIONEER HI BRED INT (US)
DU PONT (US)
ABAD ANDRE (US)
DONG HUA (US)
HERRMANN RAFAEL (US)
LU ALBERT (US)
MCCUTCHEN BILLY F (US)
RICE JANET A (US)
SCHEPERS ERIC J (US)
WONG JAMES F (US)
DU PONT (US)
ABAD ANDRE (US)
DONG HUA (US)
HERRMANN RAFAEL (US)
LU ALBERT (US)
MCCUTCHEN BILLY F (US)
RICE JANET A (US)
SCHEPERS ERIC J (US)
WONG JAMES F (US)
International Classes:
C07K14/325; C12N15/82; (IPC1-7): C07K14/325; C12N15/82
Domestic Patent References:
| WO2002034774A2 | 2002-05-02 | |||
| WO2004003148A2 | 2004-01-08 |
Other References:
DATABASE EMBL [online] 1 January 1998 (1998-01-01), PECHAN, T, XP002325016, retrieved from FASTA Database accession no. O22499
DATABASE EMBL 28 May 2002 (2002-05-28), XP002325017, retrieved from FASTA Database accession no. AY112465
DATABASE EMBL 28 May 2002 (2002-05-28), XP002325017, retrieved from FASTA Database accession no. AY112465
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