HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF

Title:

HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2001/002359

Kind Code:

A1

Abstract:

Heterocyclic compounds represented by the following general formula which have inhibitory effects on AP-1 activity, NF-Kappa B activity, inflammatory cytokine production, matrix metalloprotease production, inflammatory cell adhesion factor expression, etc. and are usable as drugs: R?1¿-C(=O)-N(R?2¿)-A-X-B-N(R?3¿)-Y-(CH¿2?)¿n?-R?4¿ wherein R?1¿ represents cycloalkyl or cycloalkenyl; R?2¿ and R?3¿ represent each hydrogen or alkyl; R?4¿ represents alkyl, a heterocycle, etc.; n is an integer of from 0 to 6; A represents a heterocycle; B represents an aromatic ring or a heterocycle; and X and Y represent each a bond or a linking group.

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Inventors:

IINO YUKIO (JP)
FUJITA KOHICHI (JP)
KODAIRA ARIKO (JP)
HATANAKA TOSHIHIRO (JP)
TAKEHANA KENJI (JP)
KOBAYASHI TSUYOSHI (JP)
KONISHI ATSUSHI (JP)
YAMAMOTO TAKASHI (JP)

Application Number:

PCT/JP2000/004298

Publication Date:

January 11, 2001

Filing Date:

June 29, 2000

Export Citation:

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Assignee:

AJINOMOTO KK (JP)
IINO YUKIO (JP)
FUJITA KOHICHI (JP)
KODAIRA ARIKO (JP)
HATANAKA TOSHIHIRO (JP)
TAKEHANA KENJI (JP)
KOBAYASHI TSUYOSHI (JP)
KONISHI ATSUSHI (JP)
YAMAMOTO TAKASHI (JP)

International Classes:

A61P29/00; C07D211/58; C07D213/75; C07D237/22; C07D239/48; C07D277/44; C07D277/46; (IPC1-7): C07D211/58; A61K31/44; A61K31/445; A61K31/50; A61K31/505; A61P29/00; C07D213/75; C07D213/76; C07D237/20; C07D237/22; C07D239/42; C07D239/48; C07D277/44

Domestic Patent References:

WO2000015603A1	2000-03-23
WO1997024343A1	1997-07-10
WO1997017958A1	1997-05-22

Other References: