Title:
HUMANIZED DR4 ANTIBODY GENE HAVING APOPTOSIS-INDUCING ACTIVITY AND DUAL-ACTING CHIMERIC ANTIGEN RECEPTOR T CELL OR NATURAL KILLER CELL THERAPEUTIC AGENT USING SAME
Document Type and Number:
WIPO Patent Application WO/2018/226020
Kind Code:
A3
Abstract:
The present invention relates to a humanized DR4 antibody gene having apoptosis-inducing activity, and a dual-acting chimeric antigen receptor T cell or natural killer cell therapeutic agent using the same. According to the present invention, a secretory DR4 scFv antibody recombinant protein, which is synthesized by using a humanized DR4 scFv antibody gene (humanized anti-DR4 scFv), may be used as an anticancer drug specifically targeting DR4 by binding to DR4 expressed on the surface of cancer cells to induce apoptosis in the cancer cells. In addition, the chimeric antigen receptor (CAR) using the humanized DR4 scFv antibody gene is predicted to have a strong anticancer immune effect as a dual-acting cell therapeutic agent, which is capable of simultaneously inducing apoptosis in cancer cells by means of DR4 and exhibiting a cytotoxic effect for cytotoxic T lymphocytes or natural killer cells, by being utilized as a DR4-specific CAR-T cell or CAR-NK cell therapeutic agent and binding to DR4 expressed on the surface of cancer cells.
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Inventors:
YOUN HYUN JOO (KR)
Application Number:
PCT/KR2018/006419
Publication Date:
January 31, 2019
Filing Date:
June 05, 2018
Export Citation:
Assignee:
UNIV INJE IND ACAD COOP FOUND (KR)
International Classes:
C07K16/28; A61K35/17; C07K16/30; C12N5/0783
Foreign References:
| KR20100034353A | 2010-04-01 | |||
| US20130156781A1 | 2013-06-20 | |||
| US20110002933A1 | 2011-01-06 | |||
| KR20110041672A | 2011-04-22 |
Other References:
LEE, SEUNG-HYUN ET AL.: "Humanization of an Agonistic Anti-death Receptor 4 Single Chain Variable Fragment Antibody and Avidity-mediated Enhancement of Its Cell Death-inducing Activity", MOLECULAR IMMUNOLOGY, vol. 47, no. 4, 2010, pages 816 - 824, XP026823538
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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