Title:
IMMUNE ASSAY
Document Type and Number:
WIPO Patent Application WO/2012/127240
Kind Code:
A3
Abstract:
The invention relates to a method of identifying a modulator of the immune response system, comprising assaying for the effect of a compound on the internalisation and recycling of CTLA-4 in a cell, wherein an increase in cycling of CTLA-4 compared to a control without the compound indicates that the compound suppresses the immune response and a decrease in the cycling of CTLA-4 compared to a control without the compound, indicates that the compound increases the immune response. The cycling of CTLA-4 may be determined by monitoring CTLA-4 or monitoring uptake of a CTLA-4 label into a cell.
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Inventors:
QURESHI OMAR SALEEM (GB)
SANSOM DAVID MICHAEL (GB)
SANSOM DAVID MICHAEL (GB)
Application Number:
PCT/GB2012/050635
Publication Date:
January 14, 2016
Filing Date:
March 22, 2012
Export Citation:
Assignee:
UNIV BIRMINGHAM (GB)
QURESHI OMAR SALEEM (GB)
SANSOM DAVID MICHAEL (GB)
QURESHI OMAR SALEEM (GB)
SANSOM DAVID MICHAEL (GB)
International Classes:
A61K38/00; G01N33/50
Foreign References:
| US20020041849A1 | 2002-04-11 | |||
| US20040106160A1 | 2004-06-03 |
Other References:
QURESHI O S ET AL: "CTLA-4 rips co-stimulatory molecules from antigen-presenting cells to regulate immune responses", IMMUNOLOGY, vol. 131, no. Suppl. 1, December 2010 (2010-12-01), & ANNUAL CONGRESS OF THE BRITISH-SOCIETY-FOR-IMMUNOLOGY; LIVERPOOL, UK; DECEMBER 06 -10, 2010, pages 43, XP008151868, ISSN: 0019-2805
O. S. QURESHI ET AL: "Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4", SCIENCE, vol. 332, no. 6029, 29 April 2011 (2011-04-29), pages 600 - 603, XP055026991, ISSN: 0036-8075, DOI: 10.1126/science.1202947
LUCY S. K. WALKER ET AL: "The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses", NATURE REVIEWS IMMUNOLOGY, vol. 11, no. 12, 1 December 2011 (2011-12-01), pages 852 - 863, XP055026995, ISSN: 1474-1733, DOI: 10.1038/nri3108
VALK E ET AL: "CTLA-4 trafficking and surface expression", TRENDS IN IMMUNOLOGY, ELSEVIER, RAHWAY, NJ, US, vol. 29, no. 6, 1 June 2008 (2008-06-01), pages 272 - 279, XP022701228, ISSN: 1471-4906, [retrieved on 20080509], DOI: 10.1016/J.IT.2008.02.011
O. S. QURESHI ET AL: "Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4", SCIENCE, vol. 332, no. 6029, 29 April 2011 (2011-04-29), pages 600 - 603, XP055026991, ISSN: 0036-8075, DOI: 10.1126/science.1202947
LUCY S. K. WALKER ET AL: "The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses", NATURE REVIEWS IMMUNOLOGY, vol. 11, no. 12, 1 December 2011 (2011-12-01), pages 852 - 863, XP055026995, ISSN: 1474-1733, DOI: 10.1038/nri3108
VALK E ET AL: "CTLA-4 trafficking and surface expression", TRENDS IN IMMUNOLOGY, ELSEVIER, RAHWAY, NJ, US, vol. 29, no. 6, 1 June 2008 (2008-06-01), pages 272 - 279, XP022701228, ISSN: 1471-4906, [retrieved on 20080509], DOI: 10.1016/J.IT.2008.02.011
Attorney, Agent or Firm:
WITHERS & ROGERS LLP et al. (London SE1 2AU, GB)
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