Title:
INFLAMMATION TARGETED NEUTROPHIL GRANULOCYTE DRUG DELIVERY SYSTEM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/041250
Kind Code:
A1
Abstract:
Disclosed is an inflammation targeted neutrophil granulocyte drug delivery system and use thereof, wherein the drug delivery system consists of neutrophil granulocytes and a therapeutic substance or a detectable substance loaded into the neutrophil granulocytes or to the surface of the neutrophil granulocytes in a direct or indirect way. Using neutrophil granulocytes as the carrier of the drug can actively target the drug to an inflammatory site, and increase the drug concentration at the inflammatory site. The neutrophil granulocytes arriving at the inflammatory site will be abnormally activated under the stimulation of cytokines, rapidly disintegrate and die in the way of "skynet". This helps to rapidly release the loaded drug to the targeted site, so as to improve the therapeutic effect and reduce the toxic and side-effects.
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Inventors:
ZHANG CAN (CN)
XUE JINGWEI (CN)
ZHAO ZEKAI (CN)
ZHANG LEI (CN)
WEN YAJING (CN)
XUE JINGWEI (CN)
ZHAO ZEKAI (CN)
ZHANG LEI (CN)
WEN YAJING (CN)
Application Number:
PCT/CN2014/092340
Publication Date:
March 24, 2016
Filing Date:
November 27, 2014
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
A61K47/46; A61K31/337; A61K31/5383; A61K48/00; A61K49/04; A61K49/08; A61P29/00
Domestic Patent References:
| WO1996040060A1 | 1996-12-19 | |||
| WO2011046842A1 | 2011-04-21 |
Other References:
SANYOG JAIN ET AL.: "RGD-anchored magnetic liposome for monocytes/neutrophils-mediated brain targeting", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 26, 31 December 2003 (2003-12-31), pages 43 - 55
JING QIN ET AL.: "Surface Modification of RGD-Liposomes for Selective Drug Delivery to Monocytes/Neutrophils in Brain", CHEM. PHARM. BULL., vol. 55, no. 8, 31 December 2007 (2007-12-31), pages 1192 - 1197, XP055018501, DOI: doi:10.1248/cpb.55.1192
QIN, JING ET AL.: "Studies on RGD-Mediated Brain-Target Ferulic Acid Liposome", CDFD MEDICAL SCIENCE AND TECHNOLOGY COMPILES, vol. 9, 15 September 2013 (2013-09-15)
WANG, SHUANG ET AL.: "Progress in Drug Delivery System for Brain Targeting", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 43, no. 12, 31 December 2012 (2012-12-31), pages 137 - 142
JING QIN ET AL.: "Surface Modification of RGD-Liposomes for Selective Drug Delivery to Monocytes/Neutrophils in Brain", CHEM. PHARM. BULL., vol. 55, no. 8, 31 December 2007 (2007-12-31), pages 1192 - 1197, XP055018501, DOI: doi:10.1248/cpb.55.1192
QIN, JING ET AL.: "Studies on RGD-Mediated Brain-Target Ferulic Acid Liposome", CDFD MEDICAL SCIENCE AND TECHNOLOGY COMPILES, vol. 9, 15 September 2013 (2013-09-15)
WANG, SHUANG ET AL.: "Progress in Drug Delivery System for Brain Targeting", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 43, no. 12, 31 December 2012 (2012-12-31), pages 137 - 142
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. et al. (CN)
南京天华专利代理有限责任公司 (CN)
南京天华专利代理有限责任公司 (CN)
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