Title:
INHIBITOR OF BRUTON TYROSINE KINASE
Document Type and Number:
WIPO Patent Application WO/2020/098716
Kind Code:
A1
Abstract:
Disclosed is a compound of formula (I) with a Btk inhibitory activity, wherein all the variables are as defined herein. The compound can be used for the treatment of diseases such as autoimmune diseases, xenogeneic immune diseases, cancers or thromboembolic diseases. Also disclosed is a pharmaceutical composition comprising a compound of formula (I). Futher provided is a compound capable of inhibiting Bruton tyrosine kinase activity by covalent binding. （I）
Inventors:
PAN ZHENGYING (CN)
JIAO ZHAODONG (CN)
LI XITAO (CN)
TAO GUANYU (CN)
SHI YANXIA (CN)
ZHANG RUI (CN)
JIAO ZHAODONG (CN)
LI XITAO (CN)
TAO GUANYU (CN)
SHI YANXIA (CN)
ZHANG RUI (CN)
Application Number:
PCT/CN2019/118136
Publication Date:
May 22, 2020
Filing Date:
November 13, 2019
Export Citation:
Assignee:
BEIJING RECIPROCAPHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/517; C07D401/04; A61P35/00
Domestic Patent References:
| WO2008068507A2 | 2008-06-12 | |||
| WO2008068507A2 | 2008-06-12 | |||
| WO2008020203A1 | 2008-02-21 | |||
| WO2013060098A1 | 2013-05-02 | |||
| WO2001098290A2 | 2001-12-27 |
Foreign References:
| CN102123991A | 2011-07-13 | |||
| CN101610676A | 2009-12-23 | |||
| US6326469B1 | 2001-12-04 |
Other References:
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PAL SINGH S ET AL., MOL CANCER, vol. 17, no. 1, 19 February 2018 (2018-02-19), pages 57
PAN ZHENGYING, SCI. REP., vol. 5, 2015, pages 16136
ARNOLD ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. A, B, 2000, pages 2167 - 2170
"Harrison's Principles of Internal", 2004, THE MCGRAW-HILL COMPANIES, INC
DEY ET AL., CYTOJOURNAL, vol. 3, no. 24, 2006
NISITANI ET AL., PROC. NATL. ACAD. SCI, USA, vol. 96, 1999, pages 2221 - 2226
HOCHHAUS ET AL., BIOMED. CHROM., vol. 6, 1992, pages 283 - 286
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
"Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
BURCHAT ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 1687 - 1690
FEDORAK ET AL., AM. J. PHYSIOL, vol. 269, 1995, pages G210 - 218
MCLOED ET AL., GASTROENTEROL, vol. 106, 1994, pages 405 - 413
J. LARSENH. BUNDGAARD, INT. J. PHARMACEUTICS, vol. 37, 1987, pages 87
J. LARSEN ET AL., INT. J. PHARMACEUTICS, vol. 47, 1988, pages 103
SINKULA ET AL., J. PHARM. SD., vol. 64, 1975, pages 181 - 210
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
EDWARD B. ROCHE: "Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
NOGRADY: "Medicinal Chemistry A Biochemical Approach", 1985, OXFORD UNIVERSITY PRESS, pages: 388 - 392
SILVERMAN: "The Organic Chemistry of Drug Design and Drug Action", 1992, ACADEMIC PRESS, INC., pages: 352 - 401
SAULNIER ET AL., BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 4, 1994, pages 1985
KUZMIC ET AL., ANAL. BIOCHEM., vol. 286, 2000, pages 45 - 50
ERIN F. DIMAURO ET AL., J. MED. CHEM., vol. 49, 2006, pages 5671 - 5686
PAL SINGH S ET AL., MOL CANCER, vol. 17, no. 1, 19 February 2018 (2018-02-19), pages 57
PAN ZHENGYING, SCI. REP., vol. 5, 2015, pages 16136
ARNOLD ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. A, B, 2000, pages 2167 - 2170
"Harrison's Principles of Internal", 2004, THE MCGRAW-HILL COMPANIES, INC
DEY ET AL., CYTOJOURNAL, vol. 3, no. 24, 2006
NISITANI ET AL., PROC. NATL. ACAD. SCI, USA, vol. 96, 1999, pages 2221 - 2226
HOCHHAUS ET AL., BIOMED. CHROM., vol. 6, 1992, pages 283 - 286
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
"Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
BURCHAT ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 1687 - 1690
FEDORAK ET AL., AM. J. PHYSIOL, vol. 269, 1995, pages G210 - 218
MCLOED ET AL., GASTROENTEROL, vol. 106, 1994, pages 405 - 413
J. LARSENH. BUNDGAARD, INT. J. PHARMACEUTICS, vol. 37, 1987, pages 87
J. LARSEN ET AL., INT. J. PHARMACEUTICS, vol. 47, 1988, pages 103
SINKULA ET AL., J. PHARM. SD., vol. 64, 1975, pages 181 - 210
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
EDWARD B. ROCHE: "Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
NOGRADY: "Medicinal Chemistry A Biochemical Approach", 1985, OXFORD UNIVERSITY PRESS, pages: 388 - 392
SILVERMAN: "The Organic Chemistry of Drug Design and Drug Action", 1992, ACADEMIC PRESS, INC., pages: 352 - 401
SAULNIER ET AL., BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 4, 1994, pages 1985
KUZMIC ET AL., ANAL. BIOCHEM., vol. 286, 2000, pages 45 - 50
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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