INHIBITORS OF POLO-LIKE KINASE

WIPO Patent Application WO/2012/048129

A3

The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

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WO/2008/081928	PYRAZOLOPYRIMIDINE COMPOUND
WO/2015/097123	NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

NEITZ R JEFFREY
TROUNG ANH P (US)
GALEMMO ROBERT A (US)
YE XIAOCONG MICHAEL
SEALY JENNIFER
ADLER MARC (US)
BOWERS SIMEON (US)
BEROZA PAUL (US)
ANDERSON JOHN P (US)
AUBELE DANIELLE L (US)
ARTIS DEAN RICHARD (GB)
HOM ROY K (US)
ZHU YONG-LIANG

PCT/US2011/055134

July 26, 2012

October 06, 2011

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ELAN PHARM INC (US)
NEITZ R JEFFREY
TROUNG ANH P (US)
GALEMMO ROBERT A (US)
YE XIAOCONG MICHAEL
SEALY JENNIFER
ADLER MARC (US)
BOWERS SIMEON (US)
BEROZA PAUL (US)
ANDERSON JOHN P (US)
AUBELE DANIELLE L (US)
ARTIS DEAN RICHARD (GB)
HOM ROY K (US)
ZHU YONG-LIANG

A61K31/519; A61K31/5377; A61K31/5383; A61P25/00; A61P25/16; A61P25/28; A61P35/00; C07D487/14; C07D487/22; C07D498/22

WO2008076392A2	2008-06-26
WO2007120752A2	2007-10-25
WO2010025073A1	2010-03-04
WO2011079118A1	2011-06-30

TESSMAN, John, William (Inc.800 Gateway Boulevar, South San Francisco CA, US)

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