JOINT REPAIR PROTEIN COMPOSITION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

WIPO Patent Application WO/2023/143530

A1

The present invention relates to a protein composition having a joint repair function. Preparation of the protein composition comprises the following steps: adding any one of or a combination of a nuclease or Benzonase nuclease of 20-35 U/mL into a cell protein extract, placing same at 37±1°C for enzymatic hydrolysis for 15-40 min, and separating and purifying the prepared enzymatic hydrolysate to obtain the protein composition. The cell protein composition obtained in the present invention has the effects of cell repair, joint repair and cartilage repair, and is used for preventing and treating any one of or a complication of traumatic arthropathy, degenerative osteoarthropathy, joint injury, refractory wound lesion, knee osteoarthrosis, and cartilage injury.

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WANG YU (CN)
GAO WENYONG (CN)
CHEN LIN (CN)
LI JIANJUN (CN)

PCT/CN2023/073596

August 03, 2023

January 28, 2023

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BEIJING DARWIN BIOTECH CO LTD (CN)

A61K38/02; A61P19/00; C07K1/14; C07K1/16

CN101810855A	2010-08-25
CN110507597A	2019-11-29

HAN JUN-ZHU; ZHU XUN-BING; WU SHI-WU; LI HUI-HUI; WANG SHENG: "Comparison of Chondrogenic Differentiation Potential of Three Mesenchymal Stem Cells", PROGRESS IN MODERN BIOMEDICINE, vol. 19, no. 12, 31 December 2019 (2019-12-31), CN , pages 2252 - 2255, XP009548152, ISSN: 1673-6273, DOI: 10.13241/j.cnki.pmb.2019.12.011

BEIJING ZHIDA TONGCHENG INTELLECTUAL PROPERTY AGENCY (CN)

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