Title:
LIGANDS DIRECTED TO THE NON-SECRETORY COMPONENT, NON-STALK REGION OF PIGR AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2001072846
Kind Code:
A3
Abstract:
The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.
Inventors:
MOSTOV KEITH E (US)
CHAPIN STEVEN J (US)
RICHMAN-EISENSTAT JANICE (CA)
CHAPIN STEVEN J (US)
RICHMAN-EISENSTAT JANICE (CA)
Application Number:
PCT/US2001/009699
Publication Date:
April 04, 2002
Filing Date:
March 26, 2001
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
MOSTOV KEITH E (US)
CHAPIN STEVEN J (US)
RICHMAN EISENSTAT JANICE (CA)
MOSTOV KEITH E (US)
CHAPIN STEVEN J (US)
RICHMAN EISENSTAT JANICE (CA)
International Classes:
A61K31/215; A61K31/70; A61K38/00; A61K39/395; A61K45/00; A61K47/42; A61K47/48; A61K48/00; A61K51/00; A61P11/00; C12N15/09; C07K7/00; C07K14/705; C07K16/28; C07K16/46; C07K19/00; C12N5/10; C12P21/04; (IPC1-7): C07K16/28; A61K39/395; A61K48/00; A61K38/00; A61K31/00; A61K31/7088; A61K47/48; C07K19/00; A61P11/00
Domestic Patent References:
| WO1997046588A1 | 1997-12-11 | |||
| WO1996021012A1 | 1996-07-11 |
Foreign References:
| US5972900A | 1999-10-26 |
Other References:
E. ECKMAN ET AL.: "In vitro transport of active alpha1-antitrypsin to the apical surface of epithelia by targeting the polymeric immunoglobulin receptor.", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 21, no. 2, August 1999 (1999-08-01), New York, NY, USA, pages 246 - 252, XP001031177
P. KRAJCI ET AL.: "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor).", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 22, no. 9, September 1992 (1992-09-01), Weinheim, Germany, pages 2309 - 2315, XP000567240
K. MOSTOV: "Transepithelial transport of immunoglobulins.", ANNUAL REVIEW OF IMMUNOLOGY, vol. 12, 1994, Palo Alto, CA, USA, pages 63 - 84, XP001053221
T. FERKOL ET AL.: "Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor.", JOURNAL OF CLINICAL INVESTIGATION, vol. 92, no. 5, November 1993 (1993-11-01), New York, NY, USA, pages 2394 - 2400, XP001053217
P. KRAJCI ET AL.: "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor).", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 22, no. 9, September 1992 (1992-09-01), Weinheim, Germany, pages 2309 - 2315, XP000567240
K. MOSTOV: "Transepithelial transport of immunoglobulins.", ANNUAL REVIEW OF IMMUNOLOGY, vol. 12, 1994, Palo Alto, CA, USA, pages 63 - 84, XP001053221
T. FERKOL ET AL.: "Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor.", JOURNAL OF CLINICAL INVESTIGATION, vol. 92, no. 5, November 1993 (1993-11-01), New York, NY, USA, pages 2394 - 2400, XP001053217
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