Title:
MARKER PEPTIDE FOR DETERMINING RISK OF DEVELOPING METABOLIC SYNDROME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/108561
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a marker substance that is capable of accurately determining the risk of developing metabolic syndrome in a human body. In other words, the present invention provides the following: marker peptides for determining the risk of developing metabolic syndrome; antibodies or aptamers that bind to the marker peptides for determining the risk of developing metabolic syndrome; a microarray in which antibodies or aptamers that bind to the marker peptides for determining the risk of developing metabolic syndrome are immobilized on a support; a method for determining the risk of developing metabolic syndrome by measuring the amount or presence/absence of the marker peptides for determining the risk of developing metabolic syndrome in a biological sample obtained from a subject; and a kit for determining the risk of developing metabolic syndrome that contains the antibodies or the aptamers, or the microarray.
Inventors:
UCHIYAMA CHIYOKO (JP)
KURITA KEI (JP)
FUKUSHIMA ERIKO (JP)
MAKI RIICHI (JP)
KURITA KEI (JP)
FUKUSHIMA ERIKO (JP)
MAKI RIICHI (JP)
Application Number:
PCT/JP2012/083889
Publication Date:
July 25, 2013
Filing Date:
December 27, 2012
Export Citation:
Assignee:
LION CORP (JP)
International Classes:
C07K14/705; C07K14/575; C07K16/26; C07K16/28; C12M1/34; G01N27/62; G01N33/53; G01N37/00
Domestic Patent References:
| WO2002079780A1 | 2002-10-10 |
Foreign References:
| JP2004194534A | 2004-07-15 | |||
| JP2005137202A | 2005-06-02 | |||
| JP2009145220A | 2009-07-02 |
Other References:
HELMERHORST, EVA J. ET AL.: "Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 29, 2008, pages 19957 - 19966, XP055081109
SEIKI ITO ET AL.: "A Study on Salivary Peptide P-C with Special Reference to Intracellular Localization of Salivary Peptide P-C like Immunoreactivity in the Human Pancreatic B- Cells", FOLIA ENDOCRINOLOGICA JAPONICA, vol. 60, no. 9, September 1984 (1984-09-01), pages 1080 - 1090, XP055156549
HAAB, BRIAN B.: "Applications of antibody array platforms.", CURRENT OPINION IN BIOTECHNOLOGY, vol. 17, no. 4, 2006, pages 415 - 421, XP005592073
"Himan/Metabolic Syndrome", NIKKEI BIO NENKAN 2012 KENKYU KAIHATSU TO SHIJO SANGYO DOKO, 13 December 2011 (2011-12-13), pages 167 - 169, XP008175017
TOSHIO MORIZANE, WAKARIYASUI IGAKU TOKEIGAKU, 1 October 2004 (2004-10-01), pages 148 - 179
AMADO, FRANCISCO ET AL.: "Salivary peptidomics.", EXPERT REVIEW OF PROTEOMICS, vol. 7, no. 5, 2010, pages 709 - 721, XP008173924
LYNN, FRANCIS, C. ET AL.: "A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.", FASEB JOURNAL, vol. 17, no. 1, 2003, pages 91 - 93, XP055156567
CABRAS, TIZIANA ET AL.: "Alterations of the salivary secretory peptidome profile in children affected by type 1 diabetes.", MOLECULAR & CELLULAR PROTEOMICS, vol. 9, no. 10, 2010, pages 2099 - 2108, XP055081111
MOL. CELL PROTEOMICS, vol. 9, no. 10, October 2010 (2010-10-01), pages 2099 - 108
NATURE GENET., vol. 42, no. 2, February 2010 (2010-02-01), pages 142 - 148
PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
See also references of EP 2805966A4
SEIKI ITO ET AL.: "A Study on Salivary Peptide P-C with Special Reference to Intracellular Localization of Salivary Peptide P-C like Immunoreactivity in the Human Pancreatic B- Cells", FOLIA ENDOCRINOLOGICA JAPONICA, vol. 60, no. 9, September 1984 (1984-09-01), pages 1080 - 1090, XP055156549
HAAB, BRIAN B.: "Applications of antibody array platforms.", CURRENT OPINION IN BIOTECHNOLOGY, vol. 17, no. 4, 2006, pages 415 - 421, XP005592073
"Himan/Metabolic Syndrome", NIKKEI BIO NENKAN 2012 KENKYU KAIHATSU TO SHIJO SANGYO DOKO, 13 December 2011 (2011-12-13), pages 167 - 169, XP008175017
TOSHIO MORIZANE, WAKARIYASUI IGAKU TOKEIGAKU, 1 October 2004 (2004-10-01), pages 148 - 179
AMADO, FRANCISCO ET AL.: "Salivary peptidomics.", EXPERT REVIEW OF PROTEOMICS, vol. 7, no. 5, 2010, pages 709 - 721, XP008173924
LYNN, FRANCIS, C. ET AL.: "A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.", FASEB JOURNAL, vol. 17, no. 1, 2003, pages 91 - 93, XP055156567
CABRAS, TIZIANA ET AL.: "Alterations of the salivary secretory peptidome profile in children affected by type 1 diabetes.", MOLECULAR & CELLULAR PROTEOMICS, vol. 9, no. 10, 2010, pages 2099 - 2108, XP055081111
MOL. CELL PROTEOMICS, vol. 9, no. 10, October 2010 (2010-10-01), pages 2099 - 108
NATURE GENET., vol. 42, no. 2, February 2010 (2010-02-01), pages 142 - 148
PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
See also references of EP 2805966A4
Attorney, Agent or Firm:
SAKAI, Hiroaki et al. (JP)
Hiroaki Sakai (JP)
Hiroaki Sakai (JP)
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