MEDIUM COMPOSITION FOR DIFFERENTIATION OF PROLIFERATIVE LIVER ORGANOID AND METHOD FOR PREPARING LIVER ORGANOID USING SAME - KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY

Title:

MEDIUM COMPOSITION FOR DIFFERENTIATION OF PROLIFERATIVE LIVER ORGANOID AND METHOD FOR PREPARING LIVER ORGANOID USING SAME

Document Type and Number:

WIPO Patent Application WO/2021/045374

Kind Code:

A1

Abstract:

The present invention relates to a medium composition for differentiation of proliferative liver organoids and a method for preparing liver organoids using same. The liver organoids prepared using the medium composition of the present invention exhibit proliferation potential that maintains the characteristics of mature liver cells even through multiple subcultures, and thus the liver organoids will be effectively utilized in predicting toxicity, predicting regeneration and inflammatory responses, drug screening, and modeling for diseases such as liver steatosis.

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Inventors:

SON MYUNG JIN (KR)
CHUNG KYUNG-SOOK (KR)
MUN SEONJU (KR)
JUNG CHO ROK (KR)
RYU JAE SUNG (KR)

Application Number:

PCT/KR2020/009035

Publication Date:

March 11, 2021

Filing Date:

July 09, 2020

Export Citation:

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Assignee:

KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)

International Classes:

C12N5/071

Domestic Patent References:

WO2014127170A1

2014-08-21

Foreign References:

US20140243227A1	2014-08-28
US20180258400A1	2018-09-13
US9765301B2	2017-09-19
US10246678B2	2019-04-02

Attorney, Agent or Firm:

FIRSTLAW P.C. (KR)

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