Title:
SELF-RENEWING LIVER ORGANOIDS
Document Type and Number:
WIPO Patent Application WO/2021/045373
Kind Code:
A1
Abstract:
The present invention relates to self-renewing liver organoids which express a specific liver-specific gene. Liver organoids according to the present invention exhibit characteristics of liver cells that are more mature than 2D-differentiated liver cells, can be subcultured up to at 67 times or more, and exhibit self-renewability, wherein the characteristics of mature liver cells are maintained even after repeated subculturing. Thus, the liver organoids can be effectively used for: predicting toxicity, regenerative response, and inflammatory response; drug screening; and modeling diseases such as liver steatosis.
Inventors:
SON MYUNG JIN (KR)
CHUNG KYUNG-SOOK (KR)
MUN SEONJU (KR)
CHO HYUN SOO (KR)
KIM DAE SOO (KR)
JUNG CHO ROK (KR)
RYU JAE SUNG (KR)
CHUNG KYUNG-SOOK (KR)
MUN SEONJU (KR)
CHO HYUN SOO (KR)
KIM DAE SOO (KR)
JUNG CHO ROK (KR)
RYU JAE SUNG (KR)
Application Number:
PCT/KR2020/009033
Publication Date:
March 11, 2021
Filing Date:
July 09, 2020
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C12N5/071
Domestic Patent References:
| WO2014127170A1 | 2014-08-21 |
Foreign References:
| US20180258400A1 | 2018-09-13 | |||
| KR20130012114A | 2013-02-01 | |||
| JP2015008686A | 2015-01-19 |
Other References:
KIM DAE‐SOO, RYU JEA‐WOON, SON MI‐YOUNG, OH JUNG‐HWA, CHUNG KYUNG‐SOOK, LEE SUGI, LEE JEONG‐JU, AHN JUN‐HO, MIN JU‐SIK, AHN JIWON,: "A liver‐specific gene expression panel predicts the differentiation status of in vitro hepatocyte models", HEPATOLOGY, vol. 66, no. 5, 1 November 2017 (2017-11-01), pages 1662 - 1674, XP055788090, ISSN: 0270-9139, DOI: 10.1002/hep.29324
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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