Title:
MELDONIUM SALTS, METHOD OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS
Document Type and Number:
WIPO Patent Application WO2005012233
Kind Code:
A8
Abstract:
New salts of Meldonium, the method of their preparation, and pharmaceutical formulation on their basis have been described. The general formula of these salts is X-(CH3)3N+NHCH2CH2COOH where X- is an acid anion selected from the group of pharmaceutically acceptable acids. Practically non-hygroscopicand/or increased thermal stability and/or lasting action Meldonium hydrogen salts of fumaric acid, phosphoric acid, oxalic acid, maleic acid, and pamoic acid as well as Meldoinum orotate and galactarate are especially suitable. Novel pharmaceutical formulations containing non-hygroscopicand/or increased thermal stability and/or lasting action 3-(2,2,2-trimethylhydrazinium) propionate salts for oral, parenteral, rectal and transdermal introduction are concurrently described.
Inventors:
KALVINSH IVARS (LV)
BIRMANS ANATOLIJS (LV)
BIRMANS ANATOLIJS (LV)
Application Number:
PCT/LV2004/000005
Publication Date:
May 19, 2005
Filing Date:
July 15, 2004
Export Citation:
Assignee:
GRINDEKS JSC (LV)
KALVINSH IVARS (LV)
BIRMANS ANATOLIJS (LV)
KALVINSH IVARS (LV)
BIRMANS ANATOLIJS (LV)
International Classes:
A61K9/00; A61K9/52; A61K31/205; C07C53/16; C07C55/07; C07C55/10; C07C55/14; C07C57/145; C07C57/15; C07C59/08; C07C59/265; C07C243/14; (IPC1-7): C07C243/12; C07C53/00; A61K31/205
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