Title:
MENISCUS REGENERATION MATERIAL
Document Type and Number:
WIPO Patent Application WO/2020/071208
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a meniscus regeneration material having a high capacity to regenerate the meniscus. This meniscus regeneration material contains a protein (A). The protein (A) has a polypeptide chain (Y) and/or a polypeptide chain (Y'). The total number of polypeptide chains (Y) and/or polypeptide chains (Y') in the protein (A) is 1 to 100. The polypeptide chain (Y) is a polypeptide chain having 2 to 200 contiguous copies of at least one amino acid sequence (X) selected from the amino acid sequences VPGVG (1) represented by SEQ ID NO:1, GVGVP (4) represented by SEQ ID NO:4, GPP, GAP, and GAHGPAGPK (3) represented by SEQ ID NO:3. The polypeptide chain (Y') is a polypeptide chain where not more than 5% of the amino acid residues of the polypeptide chain (Y) are substituted with lysine and/or arginine residues. The total number of the lysine and/or arginine residues is 1 to 100. The total proportion of β-turn structures and random coil structures in the protein (A) as determined by circular dichroism spectroscopy is 60%-85%. The total number of the amino acid residues constituting the amino acid sequence (X) and the amino acid residues constituting an amino acid sequence (X') relative to the total amino acid residues in the protein (A) is 50%-70%, wherein the amino acid sequence (X') is an amino acid sequence where not more than 60% of the amino acid residues of the amino acid sequence (X) are substituted with lysine and/or arginine residues.
Inventors:
ADACHI NOBUO (JP)
KAMEI NAOSUKE (JP)
ISHIKAWA MASAKAZU (JP)
NAKASA TOMOYUKI (JP)
KAWABATA SHINGO (JP)
YAMANAKA TSUBASA (JP)
KAMEI NAOSUKE (JP)
ISHIKAWA MASAKAZU (JP)
NAKASA TOMOYUKI (JP)
KAWABATA SHINGO (JP)
YAMANAKA TSUBASA (JP)
Application Number:
PCT/JP2019/037589
Publication Date:
April 09, 2020
Filing Date:
September 25, 2019
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
SANYO CHEMICAL IND LTD (JP)
SANYO CHEMICAL IND LTD (JP)
International Classes:
A61L27/22; A61L27/36
Foreign References:
| JP2009508540A | 2009-03-05 | |||
| JP2014530698A | 2014-11-20 | |||
| JP2017186264A | 2017-10-12 | |||
| JP2013176547A | 2013-09-09 | |||
| JPS6338259B2 | 1988-07-29 | |||
| JP2012236112A | 2012-12-06 | |||
| JP3338441B2 | 2002-10-28 | |||
| JP4088341B2 | 2008-05-21 |
Other References:
KANO, TOSHIYA ET AL: "Creation of next-generation meniscustreatment using thermo-sensitive gel (silkelastin)", THE JOURNAL OF JAPANESE ORTHOPAEDIC SURGICAL SOCIETY, vol. 92, no. 8, August 2018 (2018-08-01), ISSN: 0021-5325
KAWABATA, SHINGO: "Creation of treatment technology for meniscus injury", SANYO KASEI NEWS, vol. 2019, no. 515, 30 November 2018 (2018-11-30), pages 1 - 4, XP009526865, ISSN: 0036-4649
"International and National Guidelines of Osteoarthritis Treatment", JAPANESE JOURNAL OF JOINT DISEASES, vol. 35, no. 1, 9 January 2016 (2016-01-09)
ALBERT L. LEHNINGERDAVID L. NELSONLEHNINGER: "Principles of Biochemistry", vol. 1, September 2010, HIROKAWA SHOTEN CO., pages: 346 - 347
"Chemistry of protein", vol. IV, 20 May 1987, TOKYO KAGAKUDOJIN, article "Zoku Seikagaku Jikken Koza 2) (Sequel to Biochemistry Experimental Course 2"
See also references of EP 3862030A4
KAWABATA, SHINGO: "Creation of treatment technology for meniscus injury", SANYO KASEI NEWS, vol. 2019, no. 515, 30 November 2018 (2018-11-30), pages 1 - 4, XP009526865, ISSN: 0036-4649
"International and National Guidelines of Osteoarthritis Treatment", JAPANESE JOURNAL OF JOINT DISEASES, vol. 35, no. 1, 9 January 2016 (2016-01-09)
ALBERT L. LEHNINGERDAVID L. NELSONLEHNINGER: "Principles of Biochemistry", vol. 1, September 2010, HIROKAWA SHOTEN CO., pages: 346 - 347
"Chemistry of protein", vol. IV, 20 May 1987, TOKYO KAGAKUDOJIN, article "Zoku Seikagaku Jikken Koza 2) (Sequel to Biochemistry Experimental Course 2"
See also references of EP 3862030A4
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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