Title:
METHOD AND APPARATUS FOR BRAIN AGE-BASED MONITORING OF AGE-RELATED COGNITIVE DECLINE
Document Type and Number:
WIPO Patent Application WO/2023/140466
Kind Code:
A1
Abstract:
Disclosed are a method and apparatus for brain age-based monitoring of age-related cognitive decline. The method for monitoring cognitive decline may comprise the steps of: estimating a structural brain age, which indicates a degree of aging in a patient's brain structure, by means of a magnetic resonance image of the patient's brain; estimating a functional brain age, which indicates a degree of aging in the patient's brain function, by means of a perfusion magnetic resonance image of the patient; estimating a metabolic brain age, which indicates a degree of aging in the patient's brain metabolism, by means of a magnetic resonance spectroscopic image of the patient; determining the patient's actual brain age on the basis of the structural brain age, functional brain age, and metabolic brain age; and determining a degree of cognitive decline of the patient on the basis of the patient's chronological age and the actual brain age.
Inventors:
LYOO IN KYOON (KR)
YOON SU JUNG (KR)
HA EUN JI (KR)
LEE HYANG WON (KR)
YOON SU JUNG (KR)
HA EUN JI (KR)
LEE HYANG WON (KR)
Application Number:
PCT/KR2022/015667
Publication Date:
July 27, 2023
Filing Date:
October 14, 2022
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
International Classes:
A61B5/00; A61B5/026; A61B5/055; A61N1/04; A61N1/20; A61N1/36
Domestic Patent References:
| WO2021161050A1 | 2021-08-19 |
Foreign References:
| KR101620302B1 | 2016-05-18 | |||
| JP2017074215A | 2017-04-20 | |||
| KR101886000B1 | 2018-08-06 |
Other References:
MACDONALD M. ETHAN; WILLIAMS REBECCA J.; RAJASHEKAR DEEPTHI; STAFFORD RANDALL B.; HANGANU ALEXADRU; SUN HONGFU; BERMAN AVERY J.L.;: "Age-related differences in cerebral blood flow and cortical thickness with an application to age prediction", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 95, 3 July 2020 (2020-07-03), US , pages 131 - 142, XP086326912, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2020.06.019
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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