Title:
METHOD FOR ASSISTING DETECTION OF HEAD AND NECK CANCER
Document Type and Number:
WIPO Patent Application WO/2019/117270
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for assisting the highly accurate detection of head and neck cancer. Provided is a method for assisting the detection of head and neck cancer with the use of, as an index, the amount of at least one member contained in a test sample separated from a living body, said member being selected from among miRNA having a base sequence represented by any of SEQ ID NOS: 162, 160, 145, 143, 146, 140, 141, 1-139, 142, 144, 147-159 and 161, an isoform (isomiR), a miRNA precursor, a transfer RNA fragment (tRF) or a non-coding RNA fragment (LincRNA, MiscRNA) thereof, wherein when the amount of at least one miRNA having a base sequence represented by any of SEQ ID NOS: 1-71 and 118-136, an isomiR, a miRNA precursor, a transfer RNA fragment or a non-coding RNA fragment thereof is larger than in a normal subject, or when the amount of at least one miRNA having a base sequence represented by any of SEQ ID NOS: 72-117 and 137-162, an isomiR, a miRNA precursor, a transfer RNA fragment or a non-coding RNA fragment thereof is smaller than in a normal subject, then a high probability of the occurrence of head and neck cancer is indicated.
More Like This:
| JP2003521896 | Description: Genome polymorphic phenomenon for predicting therapeutic response |
| WO/2020/102095 | AVAPRITINIB RESISTANCE OF KIT MUTANTS |
| WO/2021/061858 | TARGETED AUTOPHAGY CONJUGATES AND METHODS |
Inventors:
TAHARA HIDETOSHI (JP)
TAHARA MAKOTO (JP)
TAHARA MAKOTO (JP)
Application Number:
PCT/JP2018/045994
Publication Date:
June 20, 2019
Filing Date:
December 13, 2018
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
International Classes:
C12Q1/6886; C12N15/113; G01N33/50
Domestic Patent References:
| WO2009150839A1 | 2009-12-17 | |||
| WO2012161124A1 | 2012-11-29 | |||
| WO2009133915A1 | 2009-11-05 | |||
| WO2012161124A1 | 2012-11-29 |
Foreign References:
| JP2009171876A | 2009-08-06 | |||
| JP2011072229A | 2011-04-14 | |||
| JP2013539018A | 2013-10-17 | |||
| JP2015502176A | 2015-01-22 | |||
| JP2015051011A | 2015-03-19 |
Other References:
RABINOWITS G. ET AL.: "Comparative Analysis of MicroRNA Expression among Benign and Malignant Tongue Tissue and Plasma of Patients with Tongue Cancer", FRONTIERS IN ONCOLOGY, vol. 7, no. 191, 29 August 2017 (2017-08-29), pages 1 - 5, XP055617704
HUANG Z. ET AL.: "A novel serum microRNA signature to screen esophageal squamous cell carcinoma", CANCER MEDICINE, vol. 6, no. 1, 30 December 2016 (2016-12-30), pages 109 - 119, XP055617705
LANGEVIN S. ET AL.: "Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers", ONCOTARGET, vol. 8, no. 47, 27 July 2017 (2017-07-27), pages 82459 - 82474, XP055617707
BOLDRUP L. ET AL.: "Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue", ONCOTARGET, vol. 8, no. 61, 30 September 2017 (2017-09-30), pages 103437 - 103448, XP055617746
MIN A. ET AL.: "MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis", BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, XP055617750
LI X. ET AL.: "Long noncording RNAs in head and neck cancer", ONCOTARGET, vol. 8, no. 6, 27 October 2017 (2017-10-27), pages 10726 - 10740, XP055617751
See also references of EP 3725897A4
HUANG Z. ET AL.: "A novel serum microRNA signature to screen esophageal squamous cell carcinoma", CANCER MEDICINE, vol. 6, no. 1, 30 December 2016 (2016-12-30), pages 109 - 119, XP055617705
LANGEVIN S. ET AL.: "Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers", ONCOTARGET, vol. 8, no. 47, 27 July 2017 (2017-07-27), pages 82459 - 82474, XP055617707
BOLDRUP L. ET AL.: "Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue", ONCOTARGET, vol. 8, no. 61, 30 September 2017 (2017-09-30), pages 103437 - 103448, XP055617746
MIN A. ET AL.: "MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis", BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, XP055617750
LI X. ET AL.: "Long noncording RNAs in head and neck cancer", ONCOTARGET, vol. 8, no. 6, 27 October 2017 (2017-10-27), pages 10726 - 10740, XP055617751
See also references of EP 3725897A4
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
Download PDF:
Previous Patent: METHOD FOR AIDING DETECTION OF PANCREATIC CANCER
Next Patent: AIR PRESSURIZATION EQUIPMENT
Next Patent: AIR PRESSURIZATION EQUIPMENT