Title:
METHOD FOR ENHANCING ACTIVITY OF PHOTOSENSITIZER BY MEANS OF MAGNETIC FIELD
Document Type and Number:
WIPO Patent Application WO/2023/109694
Kind Code:
A1
Abstract:
Disclosed is a method for enhancing the activity of a photosensitizer by means of a magnetic field. In the method, under an illumination condition, the photosensitizer is placed in a magnetic field, which can improve the cytotoxicity of the photosensitizer to tumor cells and improve the activity of the photosensitizer. Then the apoptosis of cancer cells or an inhibitory effect on tumor issue is further enhanced by means of a photodynamic therapy method, which is helpful to improving an effect of photodynamic therapy.
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Inventors:
ZHANG JUNLONG (CN)
GAO SONG (CN)
YANG ZISHU (CN)
ZHOU LINAN (CN)
ZHANG SHAOJUN (CN)
WANG BINGWU (CN)
GAO SONG (CN)
YANG ZISHU (CN)
ZHOU LINAN (CN)
ZHANG SHAOJUN (CN)
WANG BINGWU (CN)
Application Number:
PCT/CN2022/138126
Publication Date:
June 22, 2023
Filing Date:
December 09, 2022
Export Citation:
Assignee:
UNIV BEIJING (CN)
UNIV SOUTH CHINA TECH (CN)
UNIV SOUTH CHINA TECH (CN)
International Classes:
A61N5/06; A61K41/00; A61P35/00
Foreign References:
| CN105214095A | 2016-01-06 | |||
| CN106668871A | 2017-05-17 | |||
| CN107812190A | 2018-03-20 | |||
| US20080221630A1 | 2008-09-11 | |||
| US20190275345A1 | 2019-09-12 |
Other References:
O MERMUT; K R DIAMOND; J-F CORMIER; P GALLANT; N Hô; S LECLAIR; J-S MAROIS; I NOISEUX; J-F MORIN; M S PATTERSON; M L VERNON: "The use of magnetic field effects on photosensitizer luminescence as a novel probe for optical monitoring of oxygen in photodynamic therapy; MFEs for optical monitoring of oxygen", PHYSICS IN MEDICINE AND BIOLOGY, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL GB, vol. 54, no. 1, 7 January 2009 (2009-01-07), Bristol GB , pages 1 - 16, XP020149768, ISSN: 0031-9155, DOI: 10.1088/0031-9155/54/1/001
LIU YAN, EDGE RUTH, HENBEST KEVIN, TIMMEL CHRISTIANE R., HORE P. J., GAST PETER: "Magnetic field effect on singlet oxygen production in a biochemical system", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, no. 2, 1 January 2005 (2005-01-01), UK , pages 174, XP093071900, ISSN: 1359-7345, DOI: 10.1039/b413489c
YAN ZHANG, SAN-XIAO ZHAO, BIN WANG, WANG JIN-JIN, WANG XIAO-RONG, ZHANG XIAO-XIN, SHI-JIA ZHOU, : "Research on Synthesis of Porphyrin Photosensitizers and Measurement of Singlet Oxygen Generation Capability", CONTEMPORARY CHEMICAL INDUSTRY, vol. 47, no. 10, 28 October 2018 (2018-10-28), pages 2062 - 2065, XP093071906, DOI: 10.13840/j.cnki.cn21-1457/tq.2018.10.016
LIU YAN, EDGE RUTH, HENBEST KEVIN, TIMMEL CHRISTIANE R., HORE P. J., GAST PETER: "Magnetic field effect on singlet oxygen production in a biochemical system", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, no. 2, 1 January 2005 (2005-01-01), UK , pages 174, XP093071900, ISSN: 1359-7345, DOI: 10.1039/b413489c
YAN ZHANG, SAN-XIAO ZHAO, BIN WANG, WANG JIN-JIN, WANG XIAO-RONG, ZHANG XIAO-XIN, SHI-JIA ZHOU, : "Research on Synthesis of Porphyrin Photosensitizers and Measurement of Singlet Oxygen Generation Capability", CONTEMPORARY CHEMICAL INDUSTRY, vol. 47, no. 10, 28 October 2018 (2018-10-28), pages 2062 - 2065, XP093071906, DOI: 10.13840/j.cnki.cn21-1457/tq.2018.10.016
Attorney, Agent or Firm:
BEIJING CONCEPT INTELLECTUAL PROPERTY AGENCY (CN)
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