Title:
METHOD OF OBTAINING INDICATOR FOR DETECTING GASTRIC CANCER AND FOR EVALUATING RISK OF GASTRIC CANCER INCIDENCE
Document Type and Number:
WIPO Patent Application WO/2014/133089
Kind Code:
A1
Abstract:
In the present invention, the amount of BARHL2 gene expression and/or the cytosine methylation frequency are used as indicators for detecting gastric cancer and for evaluating the risk the incidence of gastric cancer. Preferably, the amount of at least one among SOX17 gene and MINT25 gene expression and/or the cytosine methylation frequency are additionally used as indicators for detecting gastric cancer and for evaluating the risk the incidence of gastric cancer.
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Inventors:
SUTO KUNIHIRO (JP)
WATANABE YOSHIYUKI (JP)
ITO FUMIO (JP)
WATANABE YOSHIYUKI (JP)
ITO FUMIO (JP)
Application Number:
PCT/JP2014/054907
Publication Date:
September 04, 2014
Filing Date:
February 27, 2014
Export Citation:
Assignee:
HITACHI CHEMICAL CO LTD (JP)
UNIV SCHOOL ST MARIANNA (JP)
UNIV SCHOOL ST MARIANNA (JP)
International Classes:
C12Q1/68; C12N15/09
Domestic Patent References:
| WO2009074328A2 | 2009-06-18 | |||
| WO2007013593A1 | 2007-02-01 |
Foreign References:
| US20090305256A1 | 2009-12-10 | |||
| JP2008283947A | 2008-11-27 |
Other References:
KOSUKE HOSOYA ET AL.: "Soki Igan no Bunshi Shindan Oyo ni Okeru BARHL 2 Idenshi Ko Methyl- ka no Yuyosei", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM KOEN SHOROKU, vol. 33, 12 September 2013 (2013-09-12), pages 54 - 55
YOSHIYUKI WATANABE ET AL.: "Igan ni Okeru Epigenetic Ijo ni Motozuita Ijisei Tahatsu Yosoku Shindan", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM KOEN SHOROKU, vol. 32, 5 September 2012 (2012-09-05), pages 29 - 30
YOSHIYUKI WATANABE ET AL.: "Pylori-kin Kansen ni Kanren no Nai Shinki Soki Igan Bunshi Marker no Dotei to Kenshin eno Oyo", JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 109, 15 September 2012 (2012-09-15)
WATANABE, Y. ET AL.: "The BARHL2 gene hypermethylation is useful as a molecular diagnostic application in early stage of gastric cancer.", THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 107, no. 1, October 2012 (2012-10-01), pages 255
YOSHIYUKI WATANABE ET AL.: "BARHL2 Ko Methyl-ka no Soki Igan Shindan eno Yuyosei", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, 2012, pages 255
WU, X. ET AL.: "CpG island hypermethylation in human astrocytomas.", CANCER RESEARCH, vol. 70, no. 7, pages 2718 - 2727
WATANABE, Y. ET AL.: "Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.", G ASTROENTEROLOGY, vol. 136, no. 7, June 2009 (2009-06-01), pages 2149 - 2158, XP026168932, DOI: doi:10.1053/j.gastro.2009.02.085
OISHI, Y . ET AL.: "Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancer.", TUMOR BIOLOGY, vol. 33, no. 2, pages 383 - 393
TIBOR, A. ET AL.: "DNA methylation biomarkers for lung cancer.", TUMOR BIOLOGY, vol. 33, no. 2, April 2012 (2012-04-01), pages 287 - 296
YOSHIYUKI WATANABE ET AL.: "Igan ni Okeru Epigenetic Ijo ni Motozuita Ijisei Tahatsu Yosoku Shindan", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM KOEN SHOROKU, vol. 32, 5 September 2012 (2012-09-05), pages 29 - 30
YOSHIYUKI WATANABE ET AL.: "Pylori-kin Kansen ni Kanren no Nai Shinki Soki Igan Bunshi Marker no Dotei to Kenshin eno Oyo", JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 109, 15 September 2012 (2012-09-15)
WATANABE, Y. ET AL.: "The BARHL2 gene hypermethylation is useful as a molecular diagnostic application in early stage of gastric cancer.", THE AMERICAN JOURNAL OF GASTROENTEROLOGY, vol. 107, no. 1, October 2012 (2012-10-01), pages 255
YOSHIYUKI WATANABE ET AL.: "BARHL2 Ko Methyl-ka no Soki Igan Shindan eno Yuyosei", PROCEEDINGS OF THE JAPANESE CANCER ASSOCIATION, 2012, pages 255
WU, X. ET AL.: "CpG island hypermethylation in human astrocytomas.", CANCER RESEARCH, vol. 70, no. 7, pages 2718 - 2727
WATANABE, Y. ET AL.: "Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.", G ASTROENTEROLOGY, vol. 136, no. 7, June 2009 (2009-06-01), pages 2149 - 2158, XP026168932, DOI: doi:10.1053/j.gastro.2009.02.085
OISHI, Y . ET AL.: "Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancer.", TUMOR BIOLOGY, vol. 33, no. 2, pages 383 - 393
TIBOR, A. ET AL.: "DNA methylation biomarkers for lung cancer.", TUMOR BIOLOGY, vol. 33, no. 2, April 2012 (2012-04-01), pages 287 - 296
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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