Title:
METHOD OF PREPARING TAXANE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1994/007879
Kind Code:
A1
Abstract:
Method of preparing taxane derivatives of formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III by means of an acid of formula (VII), elimination of protection groupings and acylation of the amine function of the side chain. The products of formula (I) have remarkable antitumor and antileukemia properties. In formulae (I) and (VII): Ar stands for aryl, R is hydrogen or acetyl, R1 is a benzoyl radical or an R2-O-CO- radical in which R2 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl, R3 is a trihalomethyl radical or phenyl substituted by a trihalomethyl radical, R4 is a hydrogen atom or is the same as R1.
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Inventors:
COMMERCON ALAIN (FR)
DIDIER ERIC (FR)
FOUQUE ELIE (FR)
DIDIER ERIC (FR)
FOUQUE ELIE (FR)
Application Number:
PCT/FR1993/000969
Publication Date:
April 14, 1994
Filing Date:
October 04, 1993
Export Citation:
Assignee:
RHONE POULENC RORER SA (FR)
COMMERCON ALAIN (FR)
DIDIER ERIC (FR)
FOUQUE ELIE (FR)
COMMERCON ALAIN (FR)
DIDIER ERIC (FR)
FOUQUE ELIE (FR)
International Classes:
A61K31/335; A61K31/337; A61K31/42; A61K31/421; A61P35/00; C07D263/04; C07D263/06; C07D305/14; C07D413/12; (IPC1-7): C07D305/14; C07D263/04; C07D413/12
Domestic Patent References:
| WO1992009589A1 | 1992-06-11 | |||
| WO1992009589A1 | 1992-06-11 |
Foreign References:
| EP0253738A1 | 1988-01-20 |
Other References:
J. MED. CHEM., vol. 34, 1991, pages 992
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