Title:
METHOD FOR PRODUCING FORM-II TYPE REDUCED COENZYME Q10 CRYSTAL OR CRYSTALLINE SOLID OF SAME, AND CRYSTALLIZING APPARATUS
Document Type and Number:
WIPO Patent Application WO/2022/202215
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method which is for producing form-II type reduced coenzyme Q10 crystals or a crystalline solid thereof, and which enables stable production of form-II type reduced coenzyme Q10 crystals or a crystalline solid thereof. A method for producing form-II type reduced coenzyme Q10 crystals or a crystalline solid thereof according to an embodiment of the present invention uses a crystallizing apparatus provided with a crystallization part, a turbidity detection part capable of detecting the turbidity in the crystallization part, and a temperature adjustment part capable of adjusting the temperature inside the crystallization part, the method comprising: housing a mixture solution containing an alcohol and reduced coenzyme Q10 in the crystallization part; adding, to the mixture solution, form-II type reduced coenzyme Q10 crystals as seed crystals; and precipitating form-II type reduced coenzyme Q10 crystals in the mixture solution after the seed crystals have been added. The precipitating includes controlling the temperature by the temperature adjustment part on the basis of the rate of change in the turbidity obtained by the turbidity detection part.
Inventors:
TANIZAKI SUBARU (JP)
ONO TADAO (JP)
HASHIMOTO TAKANORI (JP)
ONO TADAO (JP)
HASHIMOTO TAKANORI (JP)
Application Number:
PCT/JP2022/009362
Publication Date:
September 29, 2022
Filing Date:
March 04, 2022
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07C41/40; B01D9/02; C07C43/23; C07C50/28
Domestic Patent References:
| WO2020045571A1 | 2020-03-05 | |||
| WO2020067275A1 | 2020-04-02 | |||
| WO2012176842A1 | 2012-12-27 | |||
| WO2021161807A1 | 2021-08-19 | |||
| WO2003006409A1 | 2003-01-23 | |||
| WO2012176842A1 | 2012-12-27 | |||
| WO2020045571A1 | 2020-03-05 |
Foreign References:
| JPH10109933A | 1998-04-28 | |||
| JP2003089669A | 2003-03-28 | |||
| JP2021053784A | 2021-04-08 |
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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