Title:
METHOD FOR REPROGRAMMING CELL
Document Type and Number:
WIPO Patent Application WO/2022/110494
Kind Code:
A1
Abstract:
Provided are a method for reprogramming a cell in the presence of one or more reprogramming factors, a reprogrammed cell obtained by using the method and use thereof, and a kit comprising the reprogramming factors.
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Inventors:
LIN WEIFENG (CN)
Application Number:
PCT/CN2020/141524
Publication Date:
June 02, 2022
Filing Date:
December 30, 2020
Export Citation:
Assignee:
CELPATEN CONSULTING PARTNERSHIP LP (CN)
International Classes:
C12N5/079; A61K35/30; A61P27/02; A61P27/06; A61P27/12; C12N5/071; C12N5/0735; C12N5/0775; C12N5/0797; C12N5/10; C12Q1/02
Domestic Patent References:
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| WO1987000195A1 | 1987-01-15 | |||
| WO2010096496A2 | 2010-08-26 |
Foreign References:
| CN104278008A | 2015-01-14 | |||
| CN111712564A | 2020-09-25 | |||
| CN108060120A | 2018-05-22 | |||
| CN105392881A | 2016-03-09 | |||
| US5843780A | 1998-12-01 | |||
| US6200806B1 | 2001-03-13 | |||
| US4767704A | 1988-08-30 | |||
| US4657866A | 1987-04-14 | |||
| US4927762A | 1990-05-22 | |||
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| US5122469A | 1992-06-16 | |||
| USRE30985E | 1982-06-29 | |||
| US6479490B2 | 2002-11-12 | |||
| USD004476S |
Other References:
LIU, QING: "The Research of The Differentiation of iPSCs into Corneal Endothelial-like Cells", MEDICINE AND HEALTH SCIENCE, CHINESE MASTER’S THESES FULL-TEXT DATABASE, 15 April 2016 (2016-04-15), pages 1 - 76, XP055937631
THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
GEORGE Q. DALEY ET AL.: "Reprogramming of human somatic cells to pluripotency with defined factors", NATURE, 2008
NORMAND ET AL.: "A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL, 1995
BELMONTE ET AL., NATURE PROTOCOLS, 2010
AUSUBEL: "Current Protocols in Molecular Biology", CURRENT PROTOCOLS, 1988
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", CURRENT PROTOCOLS, 2002
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
CRANETRAINOR, ANNU. REV. CELL DEV. BIOL., vol. 22, 2006, pages 267 - 86
HAM ET AL., METH. ENZ., vol. 58, 1979, pages 44
BARNES ET AL., ANAL. BIOCHEM., vol. 102, 1980, pages 255
MENENDEZ ET AL., PNAS, vol. 108, no. 48, 29 November 2011 (2011-11-29), pages 19240 - 19245
LEE ET AL., STEM CELLS, vol. 25, no. 8, 2007, pages 1931 - 1939
NAGOSHI ET AL., JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 107, 2009, pages 1046 - 1052
BLUM, BRAIN RESEARCH BULLETIN, vol. 83, 2010, pages 189 - 193
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 51, no. 8, 2010, pages 3935 - 3942
CURRENT EYE RESEARCH, vol. 34, 2009, pages 347 - 354
LIU, C.HU, X.LI, Y.LU, W.LI, W.CAO, N.ZHU, S.CHENG, J.DING, S.ZHANG, M.: "Conversion of mouse fibroblasts into oligodendrocyte progenitor-like cells through a chemical approach", JOURNAL OF MOLECULAR CELL BIOLOGY., 2019
WANG, H.CAO, N.SPENCER, C.I.NIE, B.MA, T.XU, T.ZHANG, Y.WANG, X.SRIVASTAVA, D.DING, S.: "Small molecules enable cardiac reprogramming of mouse fibroblasts with a ingl factor", CELL REPORTS, vol. 6, 2014, pages 951 - 960, XP055367029, DOI: 10.1016/j.celrep.2014.01.038
ZHOU, T. ET AL.: "Generation of human induced pluripotent stem cells from urine samples", NATURE PROTOCOLS, vol. 7, 2012, pages 2080 - 2089, XP055140462, DOI: 10.1038/nprot.2012.115
KIM, D. ET AL.: "TopHat 2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions", GENOME BIOLOGY, 2011, pages 14
LIAO ET AL.: "FeatureCounts: an efficient general-purpose program for assigning sequence reads to genomic features", BIOINFORMATICS, vol. 30, 2014, pages 923 - 930, XP055693027, DOI: 10.1093/bioinformatics/btt656
DAVID RISSO ET AL.: "Normalization of RNA-seq data using factor analysis of control genes or samples", NATURE BIOTECHNOLOGY, vol. 32, 2014, pages 896 - 902, XP055614148, DOI: 10.1038/nbt.2931
ROBINSON, M.D. ET AL.: "edgeR: a Bioconductor package for differential expression analysis of digital gene expression data", BIOINFORMATICS, vol. 26, 2010, pages 139 - 140, XP055750957, DOI: 10.1093/bioinformatics/btp616
BENJAMINIHOCHBERG: "Controlling the false discovery rate: a practical and powerful approach to multiple testing", JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B, vol. 57, 1995, pages 289 - 300
THOMSON ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
GEORGE Q. DALEY ET AL.: "Reprogramming of human somatic cells to pluripotency with defined factors", NATURE, 2008
NORMAND ET AL.: "A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin", IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL, 1995
BELMONTE ET AL., NATURE PROTOCOLS, 2010
AUSUBEL: "Current Protocols in Molecular Biology", CURRENT PROTOCOLS, 1988
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", CURRENT PROTOCOLS, 2002
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
CRANETRAINOR, ANNU. REV. CELL DEV. BIOL., vol. 22, 2006, pages 267 - 86
HAM ET AL., METH. ENZ., vol. 58, 1979, pages 44
BARNES ET AL., ANAL. BIOCHEM., vol. 102, 1980, pages 255
MENENDEZ ET AL., PNAS, vol. 108, no. 48, 29 November 2011 (2011-11-29), pages 19240 - 19245
LEE ET AL., STEM CELLS, vol. 25, no. 8, 2007, pages 1931 - 1939
NAGOSHI ET AL., JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 107, 2009, pages 1046 - 1052
BLUM, BRAIN RESEARCH BULLETIN, vol. 83, 2010, pages 189 - 193
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 51, no. 8, 2010, pages 3935 - 3942
CURRENT EYE RESEARCH, vol. 34, 2009, pages 347 - 354
LIU, C.HU, X.LI, Y.LU, W.LI, W.CAO, N.ZHU, S.CHENG, J.DING, S.ZHANG, M.: "Conversion of mouse fibroblasts into oligodendrocyte progenitor-like cells through a chemical approach", JOURNAL OF MOLECULAR CELL BIOLOGY., 2019
WANG, H.CAO, N.SPENCER, C.I.NIE, B.MA, T.XU, T.ZHANG, Y.WANG, X.SRIVASTAVA, D.DING, S.: "Small molecules enable cardiac reprogramming of mouse fibroblasts with a ingl factor", CELL REPORTS, vol. 6, 2014, pages 951 - 960, XP055367029, DOI: 10.1016/j.celrep.2014.01.038
ZHOU, T. ET AL.: "Generation of human induced pluripotent stem cells from urine samples", NATURE PROTOCOLS, vol. 7, 2012, pages 2080 - 2089, XP055140462, DOI: 10.1038/nprot.2012.115
KIM, D. ET AL.: "TopHat 2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions", GENOME BIOLOGY, 2011, pages 14
LIAO ET AL.: "FeatureCounts: an efficient general-purpose program for assigning sequence reads to genomic features", BIOINFORMATICS, vol. 30, 2014, pages 923 - 930, XP055693027, DOI: 10.1093/bioinformatics/btt656
DAVID RISSO ET AL.: "Normalization of RNA-seq data using factor analysis of control genes or samples", NATURE BIOTECHNOLOGY, vol. 32, 2014, pages 896 - 902, XP055614148, DOI: 10.1038/nbt.2931
ROBINSON, M.D. ET AL.: "edgeR: a Bioconductor package for differential expression analysis of digital gene expression data", BIOINFORMATICS, vol. 26, 2010, pages 139 - 140, XP055750957, DOI: 10.1093/bioinformatics/btp616
BENJAMINIHOCHBERG: "Controlling the false discovery rate: a practical and powerful approach to multiple testing", JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B, vol. 57, 1995, pages 289 - 300
Attorney, Agent or Firm:
CHINA SMART INTELLECTUAL PROPERTY LTD. (CN)
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