METHOD OF SELECTING DNA SEQUENCE WITH TRANSCRIPTION MODULATING ACTIVITY USING A VECTOR COMPRISING AN ELEMENT WITH A GENE TRANSCRIPTION REPRESSING ACTIVITY

Title:

METHOD OF SELECTING DNA SEQUENCE WITH TRANSCRIPTION MODULATING ACTIVITY USING A VECTOR COMPRISING AN ELEMENT WITH A GENE TRANSCRIPTION REPRESSING ACTIVITY

Document Type and Number:

WIPO Patent Application WO2003004704

Kind Code:

A3

Abstract:

The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to protein production, diagnostics, transgenic plants and animals, and the therapeutic field.

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Inventors:

OTTE ARIE PIETER (NL)
KRUCKEBERG ARTHUR LEO (NL)

Application Number:

PCT/NL2002/000390

Publication Date:

October 16, 2003

Filing Date:

June 14, 2002

Export Citation:

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Assignee:

CHROMAGENICS BV (NL)
OTTE ARIE PIETER (NL)
KRUCKEBERG ARTHUR LEO (NL)

International Classes:

A61K48/00; C12N15/09; C07K14/47; C12N15/10; C12N15/67; C12N15/82; C12N15/85; C12Q1/68; (IPC1-7): C12Q1/68

Domestic Patent References:

WO2000009749A1	2000-02-24
WO1998011207A2	1998-03-19

Other References:

VAN DER VLAG JOHAN ET AL: "Transcriptional repression mediated by polycomb group proteins and other chromatin-associated repressors is selectively blocked by insulators.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 1, 7 January 2000 (2000-01-07), pages 697 - 704, XP002190168, ISSN: 0021-9258
KWAKS TED H J ET AL: "Identification of anti-repressor elements that confer high and stable protein production in mammalian cells.", NATURE BIOTECHNOLOGY, vol. 21, no. 5, 20 May 2003 (2003-05-20), pages 553 - 558, XP002246849, ISSN: 1087-0156

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