METHOD OF USING AN IMPROVED PEPTIDE NUCLEIC ACID UNIVERSAL LIBRARY TO OPTIMIZE DNA SEQUENCE HYBRIDATION

WIPO Patent Application WO2000002899

A9

Provided herein is a system, comprising three key integrated components, which permits the rapid identification of peptide nucleic acid (PNA) oligomers useful as therapeutics, diagnostics and/or gene characterization tools. The first component is a universal PNA library that may be easily and efficiently synthesized and that most preferably incorporates one or more universal nucleotide bases into carefully selected positions within each oligomer species of the library thereby providing the library with the screening ability of a larger library without requiring synthesis of a corresponding large number of individual species. The second component in this system is a high throughput screening system that includes a number of assays designed to provide information on the binding activities of the different sequence PNAs to the target nucleotide sequence (generally, a DNA or RNA sequence). The third component of the present invention is a software system especially designed to provide rapid analysis of the data collected from the high throughput screening system and to determine therefrom the sequence base identities and sequence lengths of PNA oligomers most likely to bind to and appropriately affect the target nucleotide molecule.

JPH08337600	PRODUCTION OF GLUCAGON
WO/2003/031489	MATRIX FOR SOLID-PHASE ORGANIC SYNTHESIS

HAHN SOONKAP
PATRON ANDREW
FAGNANI ROBERTO

PCT/US1999/014969

July 27, 2000

July 01, 1999

Click for automatic bibliography generation  

BIOCEPT INC (US)

C07K1/04; C07K14/00; C12Q1/68; C12N15/09; G06F17/30; (IPC1-7): C07K1/04; C07K14/00; C12Q1/68

View/Download PDF      PDF Help

Previous Patent: DELTA CLEAVAGE PRODUCTS AND METHODS BASED THEREON

Next Patent: NOVEL INHIBITORS OF ANGIOGENESIS AND TUMOR GROWTH